# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | Ritlecitinib (PF-06651600) | 11 | t1/2 | = | 37 | min | ALA4005741 | hr | Macaca mulatta | |||
2. | Voxelotor (GBT440) | 36; GBT440 | t1/2 | = | 20 | hr | ALA4004658 | hr | Macaca mulatta | |||
3. | ALA1807446 | 24 | IC50 | = | 382 | nM | ALA1811286 | 6.42 | nM | Macaca mulatta | ||
4. | ALA1761524 | 18a | Activity | = | 15 | % | ALA1764220 | % | Macaca mulatta | |||
5. | ALA2204352 | [11C](S)-10c | Stability | = | 100.4 | % | ALA2210961 | % | Macaca mulatta | |||
6. | ALA2031738 | [18F]9 | Stability | = | 98.4 | % | ALA2034114 | % | Macaca mulatta | |||
7. | ALA3088243 | [18F]11, [18F]FIMX | Stability | = | 98.1 | % | ALA3089870 | % | Macaca mulatta | |||
8. | ALA3088243 | [18F]11, [18F]FIMX | Drug uptake | 0 | ALA3089866 | Active | Macaca mulatta | |||||
9. | ALA2335071 | 1, [18F]4F-MHPG | SUV | = | 3.6 | ALA2429042 | Macaca mulatta | |||||
10. | ALA480193 | [18F]9 | Drug uptake | = | 93.4 | % | ALA992238 | % | Macaca mulatta | |||
11. | GSK690693 | 3g, GSK-690693 | Drug uptake | = | 3 | uM | ALA1028951 | uM | Macaca mulatta | |||
12. | ALA253176 | [11C]7 | Stability | = | 94.5 | % | ALA926439 | % | Macaca mulatta | |||
13. | ALA253176 | [11C]7 | Stability | = | 96.2 | % | ALA926438 | % | Macaca mulatta | |||
14. | ALA253596 | [11C] 3 | Stability | = | 96.5 | % | ALA926103 | % | Macaca mulatta | |||
15. | ALA253597 | [11C]10 | Stability | = | 95.8 | % | ALA926103 | % | Macaca mulatta | |||
16. | ALA251953 | (R)-PK-11195 | Fu | 0 | ALA924978 | Not Determined | Macaca mulatta | |||||
17. | ALA401000 | DAA 1106 | Fu | 0 | ALA924978 | Not Determined | Macaca mulatta | |||||
18. | ALA253597 | [11C]10 | Fu | = | 5.6 | % | ALA924978 | Macaca mulatta | ||||
19. | ALA253596 | [11C] 3 | Fu | = | 0.15 | % | ALA924978 | Macaca mulatta | ||||
20. | ALA388810 | [18F]3 | Drug uptake | = | 33.9 | % | ALA888774 | % | Macaca mulatta |