# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA5199640 | 16 | EC50 | = | 2.43 | uM | ALA5128250 | 5.61 | nM | Canis lupus familiaris | ||
2. | Resveratrol | 1 (Resveratrol) | EC50 | = | 7.44 | uM | ALA5128250 | 5.13 | nM | Canis lupus familiaris | ||
3. | ALA4077074 | 35 | beta t1/2 | = | 0.025 | hr | ALA4059211 | hr | Canis lupus familiaris | |||
4. | FN-1501 | 50; FN-1501 | beta t1/2 | = | 0.257 | hr | ALA4059211 | hr | Canis lupus familiaris | |||
5. | ALA4077074 | 35 | CLH | = | 1327.7 | ml/min.kg | ALA4059212 | mL.min-1.kg-1 | Canis lupus familiaris | |||
6. | FN-1501 | 50; FN-1501 | CLH | = | 129.3 | ml/min.kg | ALA4059212 | mL.min-1.kg-1 | Canis lupus familiaris | |||
7. | ALA4074184 | 3 | Drug metabolism | 0 | ALA4057818 | Metabolite_Detected | Canis lupus familiaris | |||||
8. | JNJ-54175446 | BDBM254266 | Stability | 0 | ALA4054700 | Stable | % | Canis lupus familiaris | ||||
9. | ALA4095741 | BDBM254332 | Drug metabolism | 0 | ALA4054705 | Metabolite_Detected | Canis lupus familiaris | |||||
10. | Osimertinib (AZD9291) | 8 | CLH | = | 95 | ml/min.kg | ALA4053824 | mL.min-1.kg-1 | Canis lupus familiaris | |||
11. | ALA4104658 | 8 | CLH | = | 63.4 | ml/min.kg | ALA4053824 | mL.min-1.kg-1 | Canis lupus familiaris | |||
12. | Osimertinib (AZD9291) | 8 | t1/2 | = | 21 | min | ALA4053819 | hr | Canis lupus familiaris | |||
13. | ALA4104658 | 8 | t1/2 | = | 31.5 | min | ALA4053819 | hr | Canis lupus familiaris | |||
14. | ALA3692450 | BDBM158621 | CLH | = | 10 | ml/min.kg | ALA4052957 | mL.min-1.kg-1 | Canis lupus familiaris | |||
15. | ALA4073390 | BDBM158654 | CLH | = | 10 | ml/min.kg | ALA4052957 | mL.min-1.kg-1 | Canis lupus familiaris | |||
16. | BAY-299 | 5b; atropisomer 2 | Fmax | = | 100 | % | ALA4051624 | % | Canis lupus familiaris | |||
17. | BAY-299 | 5b; atropisomer 2 | CLH | < | 0.001 | L/hr/kg | ALA4051616 | mL.min-1.kg-1 | Canis lupus familiaris | |||
18. | BAY-60-7550 | table 2 BAY-607550 | Drug metabolism | 0 | ALA4049164 | Metabolite_Detected | Canis lupus familiaris | |||||
19. | ALA4096948 | 8g | Drug metabolism | 0 | ALA4049170 | Metabolite_Detected | Canis lupus familiaris | |||||
20. | ALA4088306 | 8d-Diastereomer 1 | Drug metabolism | 0 | ALA4049170 | Metabolite_Detected | Canis lupus familiaris |