Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Comment	Assay	Assay Organism
1.	(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one	BDBM9488	Drug uptake	=	119.8	nM	ALA3803298		nM	Rattus norvegicus
2.	(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one	BDBM9488	Drug uptake	=	80.7	nM	ALA3803297		nM	Rattus norvegicus
3.	(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one	BDBM9488	Drug uptake	=	26.1	nM	ALA3803296		nM	Rattus norvegicus
4.	(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one	BDBM9488	Drug uptake	=	5.4	nM	ALA3803295		nM	Rattus norvegicus
5.	(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one	BDBM9488	Drug uptake		0		ALA3803294	BLD		Rattus norvegicus
6.	(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one	BDBM9488	Drug uptake		0		ALA3803293	BLD		Rattus norvegicus
7.	(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one	BDBM9488	Drug uptake		0		ALA3803292	BLD		Rattus norvegicus
8.	ALA3800282	5c	Drug uptake	=	0.01	uM	ALA3802086		uM	Rattus norvegicus
9.	ALA3799347	3b	Drug uptake	=	0.05	uM	ALA3802086		uM	Rattus norvegicus
10.	ALA3797869	15h	Drug uptake	=	0.15	uM	ALA3802086		uM	Rattus norvegicus
11.	ALA3800284	13e	Drug uptake	=	0.07	uM	ALA3802086		uM	Rattus norvegicus
12.	ALA3800053	13a	Drug uptake	=	0.5	uM	ALA3802086		uM	Rattus norvegicus
13.	ALA3765778	27	Drug uptake	=	711	nM	ALA3766134		nM	Rattus norvegicus
14.	ALA3765778	27	Drug uptake	=	211	nM	ALA3766133		nM	Rattus norvegicus
15.	ALA3765778	27	Drug uptake	=	21	nM	ALA3766132		nM	Rattus norvegicus
16.	ALA3765778	27	Drug uptake	=	906	nM	ALA3766131		nM	Rattus norvegicus
17.	ALA3765778	27	Drug uptake	=	399	nM	ALA3766130		nM	Rattus norvegicus
18.	ALA3765778	27	Drug uptake	=	26	nM	ALA3766129		nM	Rattus norvegicus
19.	ALA3747016	25	t1/2	=	4.12	hr	ALA3749226		hr	Rattus norvegicus
20.	ALA3747016	25	AUC	=	380	hr.ng/ml	ALA3749223		ng.hr.mL-1	Rattus norvegicus

1.

(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one

BDBM9488

Drug uptake

=

119.8

nM

ALA3803298

nM

Rattus norvegicus

2.

(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one

BDBM9488

Drug uptake

=

80.7

nM

ALA3803297

nM

Rattus norvegicus

3.

(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one

BDBM9488

Drug uptake

=

26.1

nM

ALA3803296

nM

Rattus norvegicus

4.

(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one

BDBM9488

Drug uptake

=

5.4

nM

ALA3803295

nM

Rattus norvegicus

5.

(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one

BDBM9488

Drug uptake

0

ALA3803294

BLD

Rattus norvegicus

6.

(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one

BDBM9488

Drug uptake

0

ALA3803293

BLD

Rattus norvegicus

7.

(4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one

BDBM9488

Drug uptake

0

ALA3803292

BLD

Rattus norvegicus

8.

ALA3800282

5c

Drug uptake

=

0.01

uM

ALA3802086

uM

Rattus norvegicus

9.

ALA3799347

3b

Drug uptake

=

0.05

uM

ALA3802086

uM

Rattus norvegicus

10.

ALA3797869

15h

Drug uptake

=

0.15

uM

ALA3802086

uM

Rattus norvegicus

11.

ALA3800284

13e

Drug uptake

=

0.07

uM

ALA3802086

uM

Rattus norvegicus

12.

ALA3800053

13a

Drug uptake

=

0.5

uM

ALA3802086

uM

Rattus norvegicus

13.

ALA3765778

27

Drug uptake

=

711

nM

ALA3766134

nM

Rattus norvegicus

14.

ALA3765778

27

Drug uptake

=

211

nM

ALA3766133

nM

Rattus norvegicus

15.

ALA3765778

27

Drug uptake

=

21

nM

ALA3766132

nM

Rattus norvegicus

16.

ALA3765778

27

Drug uptake

=

906

nM

ALA3766131

nM

Rattus norvegicus

17.

ALA3765778

27

Drug uptake

=

399

nM

ALA3766130

nM

Rattus norvegicus

18.

ALA3765778

27

Drug uptake

=

26

nM

ALA3766129

nM

Rattus norvegicus

19.

ALA3747016

25

t1/2

=

4.12

hr

ALA3749226

hr

Rattus norvegicus

20.

ALA3747016

25

AUC

=

380

hr.ng/ml

ALA3749223

ng.hr.mL-1

Rattus norvegicus