Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	ALA2381667	12	Ki	=	164.503	nM	ALA2383481	6.78		nM	Homo sapiens
2.	ALA2381668	13	Ki	=	24.228	nM	ALA2383481	7.62		nM	Homo sapiens
3.	ALA2381665	14	Ki	=	43.053	nM	ALA2383481	7.37		nM	Homo sapiens
4.	ALA2381666	15	Ki	=	22.01	nM	ALA2383481	7.66		nM	Homo sapiens
5.	ALA2381664	16	Ki	=	302.096	nM	ALA2383481	6.52		nM	Homo sapiens
6.	ALA2381662	17	Ki	=	310.286	nM	ALA2383481	6.51		nM	Homo sapiens
7.	ALA2381663	18	Ki	=	52.11	nM	ALA2383481	7.28		nM	Homo sapiens
8.	ALA2381661	19	Ki	=	61.484	nM	ALA2383481	7.21		nM	Homo sapiens
9.	[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid	20	Ki	=	72.288	nM	ALA2383481	7.14		nM	Homo sapiens
10.	ALA2381670	21	Ki	=	73.327	nM	ALA2383481	7.13		nM	Homo sapiens
11.	ALA2381660	22	Ki	=	64.409	nM	ALA2383481	7.19		nM	Homo sapiens
12.	ALA2381659	24	Ki	=	228.782	nM	ALA2383481	6.64		nM	Homo sapiens
13.	ALA2381658	25	Ki	=	102.463	nM	ALA2383481	6.99		nM	Homo sapiens
14.	[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid	20	INH		0		ALA2383477		Active	%	Homo sapiens
15.	[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid	20	INH		0		ALA2383476		Active	%	Homo sapiens
16.	[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid	20	Ki	=	72	nM	ALA2383473	7.14		nM	Homo sapiens
17.	[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid	20	Ki	=	75	nM	ALA2383472	7.12		nM	Homo sapiens
18.	[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid	20	Ki	=	142	nM	ALA2383471	6.85		nM	Homo sapiens
19.	[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid	20	Ki	=	699	nM	ALA2383470	6.16		nM	Homo sapiens
20.	[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid	20	Ki	=	604	nM	ALA2383469	6.22		nM	Homo sapiens

1.

ALA2381667

12

Ki

=

164.503

nM

ALA2383481

6.78

nM

Homo sapiens

2.

ALA2381668

13

Ki

=

24.228

nM

ALA2383481

7.62

nM

Homo sapiens

3.

ALA2381665

14

Ki

=

43.053

nM

ALA2383481

7.37

nM

Homo sapiens

4.

ALA2381666

15

Ki

=

22.01

nM

ALA2383481

7.66

nM

Homo sapiens

5.

ALA2381664

16

Ki

=

302.096

nM

ALA2383481

6.52

nM

Homo sapiens

6.

ALA2381662

17

Ki

=

310.286

nM

ALA2383481

6.51

nM

Homo sapiens

7.

ALA2381663

18

Ki

=

52.11

nM

ALA2383481

7.28

nM

Homo sapiens

8.

ALA2381661

19

Ki

=

61.484

nM

ALA2383481

7.21

nM

Homo sapiens

9.

[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid

20

Ki

=

72.288

nM

ALA2383481

7.14

nM

Homo sapiens

10.

ALA2381670

21

Ki

=

73.327

nM

ALA2383481

7.13

nM

Homo sapiens

11.

ALA2381660

22

Ki

=

64.409

nM

ALA2383481

7.19

nM

Homo sapiens

12.

ALA2381659

24

Ki

=

228.782

nM

ALA2383481

6.64

nM

Homo sapiens

13.

ALA2381658

25

Ki

=

102.463

nM

ALA2383481

6.99

nM

Homo sapiens

14.

[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid

20

INH

0

ALA2383477

Active

%

Homo sapiens

15.

[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid

20

INH

0

ALA2383476

Active

%

Homo sapiens

16.

[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid

20

Ki

=

72

nM

ALA2383473

7.14

nM

Homo sapiens

17.

[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid

20

Ki

=

75

nM

ALA2383472

7.12

nM

Homo sapiens

18.

[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid

20

Ki

=

142

nM

ALA2383471

6.85

nM

Homo sapiens

19.

[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid

20

Ki

=

699

nM

ALA2383470

6.16

nM

Homo sapiens

20.

[(1S)-1-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-bromobutyl]boronic acid

20

Ki

=

604

nM

ALA2383469

6.22

nM

Homo sapiens