Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	BMS 453	1, BMS-189453	Activity		0		ALA5044503		Not Active		Homo sapiens
2.	TLX agonist 1	2; ccrp2	Activity		0		ALA5044502		Not Active		Homo sapiens
3.	BMS 453	1, BMS-189453	Activity		0		ALA5044501		Active		Homo sapiens
4.	TLX agonist 1	2; ccrp2	Activity		0		ALA5044500		Active		Homo sapiens
5.	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline	16	Activity		0		ALA5044498		Active		Homo sapiens
6.	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide	10	TdeltaS	=	123	kcal/mol	ALA5044497			kcal/mol	Homo sapiens
7.	ALA5079729	5	Activity		0		ALA5044495		Not Active		Homo sapiens
8.	ALA5082019	6	Activity		0		ALA5044495		Not Active		Homo sapiens
9.	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide	10	Activity		0		ALA5044492		Active		Homo sapiens
10.	TLX agonist 1	2; ccrp2	Activity		0		ALA5044491		Active		Homo sapiens
11.	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide	10	EC50	=	5	uM	ALA5044486	5.30		nM	Homo sapiens
12.	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide	10	deltaH	=	114	kcal/mol	ALA5044485			kcal/mol	Homo sapiens
13.	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide	10	Kd	=	1.6	uM	ALA5044484	5.80		nM	Homo sapiens
14.	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline	16	deltaTm	=	-1.69	degrees C	ALA5044483			degrees C	Homo sapiens
15.	TLX agonist 1	2; ccrp2	deltaTm	=	-1.08	degrees C	ALA5044483			degrees C	Homo sapiens
16.	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide	10	EC50	=	0.7	uM	ALA5044482	6.16		nM	Homo sapiens
17.	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide	10	EC50	=	0.25	uM	ALA5044481	6.60		nM	Homo sapiens
18.	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline	16	EC50	=	20	uM	ALA5044481	4.70		nM	Homo sapiens
19.	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide	10	pEC50	=	6.6		ALA5044481	6.60		nM	Homo sapiens
20.	ALA5089826	9	EC50	=	1.2	uM	ALA5044481	5.92		nM	Homo sapiens

1.

BMS 453

1, BMS-189453

Activity

0

ALA5044503

Not Active

Homo sapiens

2.

TLX agonist 1

2; ccrp2

Activity

0

ALA5044502

Not Active

Homo sapiens

3.

BMS 453

1, BMS-189453

Activity

0

ALA5044501

Active

Homo sapiens

4.

TLX agonist 1

2; ccrp2

Activity

0

ALA5044500

Active

Homo sapiens

5.

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

16

Activity

0

ALA5044498

Active

Homo sapiens

6.

2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

10

TdeltaS

=

123

kcal/mol

ALA5044497

kcal/mol

Homo sapiens

7.

ALA5079729

5

Activity

0

ALA5044495

Not Active

Homo sapiens

8.

ALA5082019

6

Activity

0

ALA5044495

Not Active

Homo sapiens

9.

2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

10

Activity

0

ALA5044492

Active

Homo sapiens

10.

TLX agonist 1

2; ccrp2

Activity

0

ALA5044491

Active

Homo sapiens

11.

2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

10

EC50

=

5

uM

ALA5044486

5.30

nM

Homo sapiens

12.

2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

10

deltaH

=

114

kcal/mol

ALA5044485

kcal/mol

Homo sapiens

13.

2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

10

Kd

=

1.6

uM

ALA5044484

5.80

nM

Homo sapiens

14.

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

16

deltaTm

=

-1.69

degrees C

ALA5044483

degrees C

Homo sapiens

15.

TLX agonist 1

2; ccrp2

deltaTm

=

-1.08

degrees C

ALA5044483

degrees C

Homo sapiens

16.

2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

10

EC50

=

0.7

uM

ALA5044482

6.16

nM

Homo sapiens

17.

2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

10

EC50

=

0.25

uM

ALA5044481

6.60

nM

Homo sapiens

18.

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

16

EC50

=

20

uM

ALA5044481

4.70

nM

Homo sapiens

19.

2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

10

pEC50

=

6.6

ALA5044481

6.60

nM

Homo sapiens

20.

ALA5089826

9

EC50

=

1.2

uM

ALA5044481

5.92

nM

Homo sapiens