Activities

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Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	ALA2387397	45	IC50	=	0.2	nM	ALA2388852	9.70		nM	Rattus norvegicus
2.	ALA2385105	20	IC50	=	0.9	nM	ALA2388852	9.05		nM	Rattus norvegicus
3.	ALA2387399	47	IC50	=	2.3	nM	ALA2388852	8.64		nM	Rattus norvegicus
4.	(3R,5R)-3-butyl-3-ethyl-7,8-dimethoxy-5-phenyl-4,5-dihydro-2H-benzo[f][1,4]thiazepine 1,1-dioxide	2	IC50	=	22	nM	ALA2388852	7.66		nM	Rattus norvegicus
5.	ALA2387419	44	IC50		0		ALA2388852		Not Determined		Rattus norvegicus
6.	ALA2387402	50	IC50		0		ALA2388852		Not Determined		Rattus norvegicus
7.	Linerixibat	56, GSK2330672	IC50	=	1.9	nM	ALA2388852	8.72		nM	Rattus norvegicus
8.	[³H]taurocholic acid	THCA	Km	=	35	uM	ALA2076520		substrate [Km=35uM]	nM	Rattus norvegicus
9.	[³H]taurocholic acid	THCA	Activity		0		ALA2076059		substrate [+]		Rattus norvegicus
10.	Glycochenodeoxycholic acid	6	Activity		0		ALA2076059		substrate [+]		Rattus norvegicus
11.	Glycocholic acid	5b, glyco	Activity		0		ALA2076059		substrate [+]		Rattus norvegicus
12.	Glycodeoxycholic acid monohydrate	7b, glyco	Activity		0		ALA2076059		substrate [+]		Rattus norvegicus
13.	Glycoursodeoxycholic Acid	9b, glyco	Activity		0		ALA2076059		substrate [+]		Rattus norvegicus
14.	Taurochenodeoxycholic acid	7	Activity		0		ALA2076059		substrate [+]		Rattus norvegicus
15.	[³H]taurocholic acid	THCA	Activity		0		ALA2076059		substrate [+]		Rattus norvegicus
16.	Taurodeoxychloic acid	7a, tauro	Activity		0		ALA2076059		substrate [+]		Rattus norvegicus
17.	tauroursodeoxycholic acid	9a, tauro	Activity		0		ALA2076059		substrate [+]		Rattus norvegicus