| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  modafinil | Modafinilc | Activity | = | 58 | % | ALA5246984 | % | Homo sapiens | |||
| 2. |  ALA5199685 | 85 | INH | 0 | ALA5167016 | NA | % | Homo sapiens | ||||
| 3. |  8-(benzotriazol-1-ylamino)octanoic acid | 7 | Ratio IC50 | = | 1.9 | ALA4406466 | Homo sapiens | |||||
| 4. |  ALA4442292 | 6 | Ratio IC50 | = | 1.7 | ALA4406466 | Homo sapiens | |||||
| 5. | 8-(benzotriazol-1-ylamino)octanoic acid | 7 | IC50 | = | 128 | uM | ALA4406459 | nM | Homo sapiens | |||
| 6. | ALA4442292 | 6 | IC50 | = | 766 | uM | ALA4406459 | nM | Homo sapiens | |||
| 7. | 8-(benzotriazol-1-ylamino)octanoic acid | 7 | IC50 | = | 244 | uM | ALA4406417 | nM | Homo sapiens | |||
| 8. | ALA4442292 | 6 | IC50 | = | 1310 | uM | ALA4406417 | nM | Homo sapiens | |||
| 9. |  (+)-Ketoconazole | SID144204227 | IC50 | = | 0.013 | uM | ALA4815192 | 7.90 | nM | Homo sapiens | ||
| 10. |  ALA4861470 | 22o | IC50 | > | 50 | uM | ALA4815192 | nM | Homo sapiens | |||
| 11. |  ALA4633246 | 37; DSM502 | IC50 | = | 5.5 | uM | ALA4605524 | 5.26 | nM | Homo sapiens | ||
| 12. | ALA4633246 | 37; DSM502 | IC50 | > | 20 | uM | ALA4605523 | nM | Homo sapiens | |||
| 13. | ALA4633246 | 37; DSM502 | IC50 | > | 20 | uM | ALA4605514 | nM | Homo sapiens | |||
| 14. | ALA4633246 | 37; DSM502 | IC50 | > | 20 | uM | ALA4605401 | nM | Homo sapiens | |||
| 15. | ALA4633246 | 37; DSM502 | IC50 | = | 5.5 | uM | ALA4605442 | 5.26 | nM | Homo sapiens | ||
| 16. | ALA4633246 | 37; DSM502 | IC50 | > | 20 | uM | ALA4605441 | nM | Homo sapiens | |||
| 17. |  ALA3508698 | [14C]Aliskiren hemifumarate, [14C]-SPP100 hemifumarate | Activity | = | 99.6 | % | ALA3508969 | VALUE = CYP3A4/5 was contributing predominantly (99.6%) to the oxidative metabolism of aliskiren | % | Homo sapiens | ||
| 18. |  Aliskiren | 2 | Inhibition | = | -16.6 | % | ALA3509382 | VALUE = Expressed as % reduction in production of metabolite from subtype-specific substrate by enzyme. Production of metabolite was increased by 16.6% | % | Homo sapiens | ||
| 19. |  Ervogastat | COVC-0149716833 | IC50 | > | 100 | uM | ALA5099715 | nM | Homo sapiens | |||
| 20. |  ALA5178371 | 3 | IC50 | > | 30 | uM | ALA5099715 | nM | Homo sapiens |
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