# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | Cobimetinib | 1, XL518, GDC-0973 | Drug uptake | = | 1.56 | uM | ALA3535735 | uM | Mus musculus | |||
2. | ALA3237591 | 5b | Drug metabolism | 0 | ALA3240072 | metabolite_detected | Mus musculus | |||||
3. | ALA3237591 | 5b | Drug uptake | 0 | ALA3240071 | Active | Mus musculus | |||||
4. | ALA3237592 | 13 | Drug metabolism | 0 | ALA3240072 | metabolite_detected | Mus musculus | |||||
5. | ALA3237592 | 13 | Drug uptake | 0 | ALA3240071 | Active | Mus musculus | |||||
6. | ALA3401467 | 18F-AmBF3-MJ9 | INH | = | 60 | % | ALA3404177 | % | Mus musculus | |||
7. | ALA3401467 | 18F-AmBF3-MJ9 | Drug uptake | = | 2.2 | % ID/g | ALA3404639 | % ID/g | Mus musculus | |||
8. | ALA3401467 | 18F-AmBF3-MJ9 | Drug uptake | = | 0.54 | % ID/g | ALA3404619 | % ID/g | Mus musculus | |||
9. | ALA3401467 | 18F-AmBF3-MJ9 | Drug uptake | = | 2.77 | % ID/g | ALA3407251 | % ID/g | Mus musculus | |||
10. | ALA3401467 | 18F-AmBF3-MJ9 | Drug uptake | = | 1.47 | % ID/g | ALA3407271 | % ID/g | Mus musculus | |||
11. | ALA3355725 | [18F]FB-ML5 | SUV | = | 0.145 | ALA3380049 | Mus musculus | |||||
12. | ALA3355725 | [18F]FB-ML5 | SUV | = | 0.041 | ALA3380688 | Mus musculus | |||||
13. | ALA3335015 | 4, oncrasin-266 | Drug uptake | = | 4.7 | ug/g | ALA3381209 | ug/g | Mus musculus | |||
14. | ALA1775135 | 34 | Drug uptake | = | 4.2 | ug/g | ALA3390321 | ug/g | Mus musculus | |||
15. | ALA3335015 | 4, oncrasin-266 | Drug uptake | = | 4.4 | ug/g | ALA3381201 | ug/g | Mus musculus | |||
16. | ALA1775135 | 34 | Drug uptake | = | 1.7 | ug/g | ALA3381201 | ug/g | Mus musculus | |||
17. | ALA3342645 | [14C]-1 | Drug uptake | = | 1.04 | mg kg-1 | ALA3382045 | mg kg-1 | Mus musculus | |||
18. | ALA3342645 | [14C]-1 | Drug uptake | = | 0.23 | mg kg-1 | ALA3382047 | mg kg-1 | Mus musculus | |||
19. | ALA3342645 | [14C]-1 | Drug uptake | = | 0.65 | mg kg-1 | ALA3382638 | mg kg-1 | Mus musculus | |||
20. | ALA3342645 | [14C]-1 | Drug uptake | = | 0.23 | mg kg-1 | ALA3382646 | mg kg-1 | Mus musculus |