Activities

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Activities

Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	ALA5278465	33	IC50	>	2	uM	ALA5252867			nM	Homo sapiens
2.	ALA5288565	29	IC50	>	2	uM	ALA5252867			nM	Homo sapiens
3.	ALA5270581	18	IC50	>	2	uM	ALA5252867			nM	Homo sapiens
4.	ALA5278787	Abbott 1141	pIC50	=	8.2		ALA5252721	8.20		nM	Homo sapiens
5.	ALA5273533	37	INH	=	75	%	ALA5244456			%	Homo sapiens
6.	ALA5281283	18	INH	=	75	%	ALA5244456			%	Homo sapiens
7.	ALA5267815	12a	INH		0		ALA5244014		Not Active	%	Homo sapiens
8.	AR-13324 M1 metabolite	13	Ki	=	0.2	nmol/L	ALA5242766	9.70		nM	Homo sapiens
9.	netarsudil	NETARSUDIL	Ki	=	1	nmol/L	ALA5242766	9.00		nM	Homo sapiens
10.	ripasudil	ripasudil	IC50	=	0.051	uM	ALA5242764	7.29		nM	Homo sapiens
11.	ALA559147	Y-27632	IC50	=	30	uM	ALA5236743	4.52		nM	Homo sapiens
12.	[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanone	SB-7720770-B	IC50	=	3	uM	ALA5236743	5.52		nM	Homo sapiens
13.	GSK 269962	6n	IC50	=	3	uM	ALA5236743	5.52		nM	Homo sapiens
14.	ALA559147	Y-27632	IC50	=	1.4	uM	ALA5236741	5.85		nM	Homo sapiens
15.	[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanone	SB-7720770-B	IC50	=	39	nM	ALA5236741	7.41		nM	Homo sapiens
16.	GSK 269962	6n	IC50	=	35	nM	ALA5236741	7.46		nM	Homo sapiens
17.	SB-747651A	26, SB-747651A	IC50	=	100	nM	ALA5236733	7.00		nM	Homo sapiens
18.	4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine	2	IC50	=	13	nM	ALA5236733	7.89		nM	Homo sapiens
19.	ALA269538	1	IC50	=	1.5	uM	ALA5235538	5.82		nM	Homo sapiens
20.	ALA4594302	17	IC50	=	24000	nM	ALA5228483	4.62		nM	Homo sapiens