Activities

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Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	[³H]NFPS	1 (NFPS)	Inhibition		0		ALA5209610		Inhibitor: Complete Inhibition At A Concentration Of 10 Μm	%	Homo sapiens
2.	Aminoacetic acid	Glycine	EC50	=	106	uM	ALA5209610		Substrate	nM	Homo sapiens
3.	(R)-NFPS	ALX5407 (2)	INH	=	80	%	ALA4434266			%	Homo sapiens
4.	7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione	Table 2, R4C1	IC50	>	200	uM	ALA4434265			nM	Homo sapiens
5.	ALA4452842	Table 2, R3C1	IC50	>	200	uM	ALA4434265			nM	Homo sapiens
6.	(R)-NFPS	ALX5407 (2)	IC50	=	14.16	nM	ALA4434265	7.85		nM	Homo sapiens
7.	ALA4439878	Table 2, R2C1	IC50	>	200	uM	ALA4434265			nM	Homo sapiens
8.	(R)-NFPS	ALX5407 (2)	INH		0		ALA4429990		Not Active	%	Homo sapiens
9.	ALA4448986	(+/-)-65	INH		0		ALA4429989		Active	%	Homo sapiens
10.	ALA4448986	(+/-)-65	IC50	=	1.06	nM	ALA4429876	8.97		nM	Homo sapiens
11.	ALA4448986	(+/-)-65	IC50	=	1.03	nM	ALA4429876	8.99		nM	Homo sapiens
12.	ALA4579970	10	IC50	=	15.1	nM	ALA4429876	7.82		nM	Homo sapiens
13.	ALA4550823	17	IC50	=	42.4	nM	ALA4429876	7.37		nM	Homo sapiens
14.	ALA4451800	18	IC50	=	29	nM	ALA4429876	7.54		nM	Homo sapiens
15.	ALA4455686	19	IC50	=	36.4	nM	ALA4429876	7.44		nM	Homo sapiens
16.	ALA4533944	20	IC50	=	38.4	nM	ALA4429876	7.42		nM	Homo sapiens
17.	ALA4458568	21	IC50	=	12.6	nM	ALA4429876	7.90		nM	Homo sapiens
18.	ALA4447922	22	IC50	=	8.4	nM	ALA4429876	8.08		nM	Homo sapiens
19.	ALA4455289	23	IC50	=	28.5	nM	ALA4429876	7.54		nM	Homo sapiens
20.	ALA4581616	29	IC50	=	339	nM	ALA4429876	6.47		nM	Homo sapiens