Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	ALA5198644	(R)-2; ErSO-DFP	IC50	=	55	uM	ALA5158039	4.26		nM	Homo sapiens
2.	ALA5169712	1	IC50	=	14	uM	ALA5158039	4.85		nM	Homo sapiens
3.	ALA5198644	(R)-2; ErSO-DFP	IC50	=	64	uM	ALA5158035	4.19		nM	Homo sapiens
4.	ALA5169712	1	IC50	=	22	uM	ALA5158035	4.66		nM	Homo sapiens
5.	A 485	A-485	Cell Proliferation EC50	>	10	uM	ALA4886649			uM	Homo sapiens
6.	ALA4521985	OL-1; 18	IC50	=	0.736	uM	ALA4481015	6.13		nM	Homo sapiens
7.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	Activity		0		ALA4839171		Active		Homo sapiens
8.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	Activity		0		ALA4839169		Active		Homo sapiens
9.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	Activity		0		ALA4839168		Active		Homo sapiens
10.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	Activity		0		ALA4839167		Active		Homo sapiens
11.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	Activity		0		ALA4839166		Active		Homo sapiens
12.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	Activity		0		ALA4839162		Dose-Dependent Effect		Homo sapiens
13.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	Activity	=	36.7	%	ALA4839161			%	Homo sapiens
14.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	Activity	=	30.5	%	ALA4839160			%	Homo sapiens
15.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	Activity		0		ALA4839158		Dose-Dependent Effect		Homo sapiens
16.	N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide	38k	INH	=	100	%	ALA4839156			%	Homo sapiens
17.	ALA4857959	39c	IC50	=	10.7	uM	ALA4839130	4.97		nM	Homo sapiens
18.	ALA4854481	39b	IC50	=	12.19	uM	ALA4839130	4.91		nM	Homo sapiens
19.	ALA4848735	39a	IC50	=	3.44	uM	ALA4839130	5.46		nM	Homo sapiens
20.	ALA4847888	38m	IC50	=	8.84	uM	ALA4839130	5.05		nM	Homo sapiens

1.

ALA5198644

(R)-2; ErSO-DFP

IC50

=

55

uM

ALA5158039

4.26

nM

Homo sapiens

2.

ALA5169712

1

IC50

=

14

uM

ALA5158039

4.85

nM

Homo sapiens

3.

ALA5198644

(R)-2; ErSO-DFP

IC50

=

64

uM

ALA5158035

4.19

nM

Homo sapiens

4.

ALA5169712

1

IC50

=

22

uM

ALA5158035

4.66

nM

Homo sapiens

5.

A 485

A-485

Cell Proliferation EC50

>

10

uM

ALA4886649

uM

Homo sapiens

6.

ALA4521985

OL-1; 18

IC50

=

0.736

uM

ALA4481015

6.13

nM

Homo sapiens

7.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

Activity

0

ALA4839171

Active

Homo sapiens

8.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

Activity

0

ALA4839169

Active

Homo sapiens

9.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

Activity

0

ALA4839168

Active

Homo sapiens

10.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

Activity

0

ALA4839167

Active

Homo sapiens

11.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

Activity

0

ALA4839166

Active

Homo sapiens

12.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

Activity

0

ALA4839162

Dose-Dependent Effect

Homo sapiens

13.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

Activity

=

36.7

%

ALA4839161

%

Homo sapiens

14.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

Activity

=

30.5

%

ALA4839160

%

Homo sapiens

15.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

Activity

0

ALA4839158

Dose-Dependent Effect

Homo sapiens

16.

N-(4-Chloro-3-(trifluoromethyl)phenyl)-4-(6-(4-(4-methylpiperazin-1-yl)phenyl)thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

38k

INH

=

100

%

ALA4839156

%

Homo sapiens

17.

ALA4857959

39c

IC50

=

10.7

uM

ALA4839130

4.97

nM

Homo sapiens

18.

ALA4854481

39b

IC50

=

12.19

uM

ALA4839130

4.91

nM

Homo sapiens

19.

ALA4848735

39a

IC50

=

3.44

uM

ALA4839130

5.46

nM

Homo sapiens

20.

ALA4847888

38m

IC50

=

8.84

uM

ALA4839130

5.05

nM

Homo sapiens