Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	ALA4764478	Example 32	EC50	=	1	nM	ALA4672979	9.00		nM	Homo sapiens
2.	ALA4755632	Example 12	EC50	<	1	nM	ALA4672979			nM	Homo sapiens
3.	ALA4800391	Example 8	EC50	<	1	nM	ALA4672979			nM	Homo sapiens
4.	ALA4755510	Example 7	EC50	<	1	nM	ALA4672979			nM	Homo sapiens
5.	ALA4787511	Example 6	EC50	<	1	nM	ALA4672979			nM	Homo sapiens
6.	ALA4757897	Example 4	EC50	<	1	nM	ALA4672979			nM	Homo sapiens
7.	ALA4764478	Example 32	IC50	<	1	nM	ALA4672978			nM	Homo sapiens
8.	ALA4755632	Example 12	IC50	<	1	nM	ALA4672978			nM	Homo sapiens
9.	ALA4800391	Example 8	IC50	<	1	nM	ALA4672978			nM	Homo sapiens
10.	ALA4755510	Example 7	IC50	<	1	nM	ALA4672978			nM	Homo sapiens
11.	ALA4787511	Example 6	IC50	<	1	nM	ALA4672978			nM	Homo sapiens
12.	ALA4757897	Example 4	IC50	<	1	nM	ALA4672978			nM	Homo sapiens
13.	ALA4867353	SR-717	EC50	=	2.1	uM	ALA4808298	5.68		nM	Homo sapiens
14.	MSA 2	62	EC50	=	24	uM	ALA4808296	4.62		nM	Homo sapiens
15.	STING agonist 3	diABZI2	EC50(app)	=	130	nM	ALA4808295	6.89		nM	Homo sapiens
16.	ALA4862898	4; ABZI	IC50(app)	=	14	uM	ALA4808294	4.85		nM	Homo sapiens
17.	2'3'-cGAMP	2',3'-cGAMP	EC50	=	5.8	nM	ALA4808283	8.24		nM	Homo sapiens
18.	(E)-2-((1-Ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-1-((E)-4-((E)-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-methoxy-5-(1H-1,2,4-triazol-5-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-7-(3-morpholinopropoxy)-2,3-dihydro-1H-benzo[d]	40	EC50	=	6.2	nM	ALA4808283	8.21		nM	Homo sapiens
19.	STING agonist 3	diABZI2	EC50	<	0.1	nM	ALA4808283			nM	Homo sapiens
20.	(E)-2-((1-Ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-1-((E)-4-((E)-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-methoxy-5-(1H-1,2,4-triazol-5-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-7-(3-morpholinopropoxy)-2,3-dihydro-1H-benzo[d]	40	Activity		0		ALA4808276		Dose-Dependent Effect		Homo sapiens

1.

ALA4764478

Example 32

EC50

=

1

nM

ALA4672979

9.00

nM

Homo sapiens

2.

ALA4755632

Example 12

EC50

<

1

nM

ALA4672979

nM

Homo sapiens

3.

ALA4800391

Example 8

EC50

<

1

nM

ALA4672979

nM

Homo sapiens

4.

ALA4755510

Example 7

EC50

<

1

nM

ALA4672979

nM

Homo sapiens

5.

ALA4787511

Example 6

EC50

<

1

nM

ALA4672979

nM

Homo sapiens

6.

ALA4757897

Example 4

EC50

<

1

nM

ALA4672979

nM

Homo sapiens

7.

ALA4764478

Example 32

IC50

<

1

nM

ALA4672978

nM

Homo sapiens

8.

ALA4755632

Example 12

IC50

<

1

nM

ALA4672978

nM

Homo sapiens

9.

ALA4800391

Example 8

IC50

<

1

nM

ALA4672978

nM

Homo sapiens

10.

ALA4755510

Example 7

IC50

<

1

nM

ALA4672978

nM

Homo sapiens

11.

ALA4787511

Example 6

IC50

<

1

nM

ALA4672978

nM

Homo sapiens

12.

ALA4757897

Example 4

IC50

<

1

nM

ALA4672978

nM

Homo sapiens

13.

ALA4867353

SR-717

EC50

=

2.1

uM

ALA4808298

5.68

nM

Homo sapiens

14.

MSA 2

62

EC50

=

24

uM

ALA4808296

4.62

nM

Homo sapiens

15.

STING agonist 3

diABZI2

EC50(app)

=

130

nM

ALA4808295

6.89

nM

Homo sapiens

16.

ALA4862898

4; ABZI

IC50(app)

=

14

uM

ALA4808294

4.85

nM

Homo sapiens

17.

2'3'-cGAMP

2',3'-cGAMP

EC50

=

5.8

nM

ALA4808283

8.24

nM

Homo sapiens

18.

(E)-2-((1-Ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-1-((E)-4-((E)-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-methoxy-5-(1H-1,2,4-triazol-5-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-7-(3-morpholinopropoxy)-2,3-dihydro-1H-benzo[d]

40

EC50

=

6.2

nM

ALA4808283

8.21

nM

Homo sapiens

19.

STING agonist 3

diABZI2

EC50

<

0.1

nM

ALA4808283

nM

Homo sapiens

20.

(E)-2-((1-Ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-1-((E)-4-((E)-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-methoxy-5-(1H-1,2,4-triazol-5-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-7-(3-morpholinopropoxy)-2,3-dihydro-1H-benzo[d]

40

Activity

0

ALA4808276

Dose-Dependent Effect

Homo sapiens