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# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA5278787 | Abbott 1141 | pIC50 | = | 7.1 | ALA5252726 | 7.10 | nM | Homo sapiens | |||
2. | ALA5273533 | 37 | INH | = | 80 | % | ALA5244431 | % | Homo sapiens | |||
3. | ALA5281283 | 18 | IC50 | > | 1000 | nM | ALA5244430 | nM | Homo sapiens | |||
4. | ALA5288938 | PROTAC 1 | IC50 | = | 2 | nM | ALA5242503 | 8.70 | nM | Homo sapiens | ||
5. | GDC-0068 | 28, GDC-0068 | IC50 | = | 5 | nM | ALA5242503 | 8.30 | nM | Homo sapiens | ||
6. | GDC-0941 | 17, GDC-0941 | INH | 0 | ALA5240751 | Not Active | % | Homo sapiens | ||||
7. | ALA5272452 | 12j | INH | = | 4.03 | % | ALA5240751 | % | Homo sapiens | |||
8. | ALA5273431 | 12g | INH | = | 1.02 | % | ALA5240751 | % | Homo sapiens | |||
9. | ALA5277445 | 12b | INH | = | 18.16 | % | ALA5240751 | % | Homo sapiens | |||
10. | ALA5288241 | B2 | INH | < | 50 | % | ALA5238274 | % | Homo sapiens | |||
11. | ALA5278392 | 9 | INH | 0 | ALA5237730 | Active | % | Homo sapiens | ||||
12. | ALA5278392 | 9 | INH | 0 | ALA5237729 | Not Active | % | Homo sapiens | ||||
13. | ALA5278392 | 9 | INH | 0 | ALA5237728 | Not Active | % | Homo sapiens | ||||
14. | ALA5278392 | 9 | INH | 0 | ALA5237727 | Not Active | % | Homo sapiens | ||||
15. | ALA5278392 | 9 | INH | 0 | ALA5237726 | Not Active | % | Homo sapiens | ||||
16. | ALA5278392 | 9 | INH | 0 | ALA5237725 | Active | % | Homo sapiens | ||||
17. | GSK690693 | 3g, GSK-690693 | IC50 | = | 2 | nM | ALA5236803 | 8.70 | nM | Homo sapiens | ||
18. | MK-2206 | 17 | IC50 | = | 5 | nM | ALA5227203 | 8.30 | nM | Homo sapiens | ||
19. | Uprosertib | UPROSERTIB | IC50 | = | 0.066 | nM | ALA5225431 | 10.18 | nM | Homo sapiens | ||
20. | Afuresertib (GSK2110183) | AFURESERTIB | IC50 | = | 0.08 | nM | ALA5225431 | 10.10 | nM | Homo sapiens |
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- IC50 4187
- Inhibition 2340
- Ki 854
- Activity 657
- Kd 563
- Residual Activity 316
- % Control 108
- Ratio 45
- Delta Tm 29
- EC50 24
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