# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | Bosentan | Bosentan | IC50 | = | 0.08 | uM | ALA5246773 | 7.10 | nM | Homo sapiens | ||
2. | ALA4438132 | 5 | IC50 | = | 0.8 | uM | ALA5246773 | 6.10 | nM | Homo sapiens | ||
3. | ALA4525321 | 4 | IC50 | = | 1.5 | uM | ALA5246773 | 5.82 | nM | Homo sapiens | ||
4. | ALA5272983 | 29 | IC50 | = | 18 | uM | ALA5246773 | 4.75 | nM | Homo sapiens | ||
5. | ALA4761843 | EUB0000348aPTSA | Ki | = | 0.46 | nM | ALA5210564 | 9.34 | nM | Homo sapiens | ||
6. | ALA4796803 | EUB0000289bCl | Ki | = | 13000 | nM | ALA5210558 | 4.89 | nM | Homo sapiens | ||
7. | ALA4761843 | EUB0000348aPTSA | IC50 | = | 0.59 | nM | ALA5210271 | 9.23 | nM | Homo sapiens | ||
8. | ALA5200705 | 26 | Activity | = | -20.7 | % | ALA5164153 | % | Homo sapiens | |||
9. | ALA5200705 | 26 | Activity | = | 1.9 | % | ALA5164129 | % | Homo sapiens | |||
10. | A 127722 | 17v | IC50 | = | 0.055 | nM | ALA4431775 | 10.26 | nM | Homo sapiens | ||
11. | A 127722 | 17v | Ki | = | 0.034 | nM | ALA4431775 | 10.47 | nM | Homo sapiens | ||
12. | ALA4568795 | 19; BQ788 | IC50 | = | 1300 | nM | ALA4431778 | 5.89 | nM | Homo sapiens | ||
13. | IRL-2500 | 13 | IC50 | = | 94 | nM | ALA4431779 | 7.03 | nM | Homo sapiens | ||
14. | Feloprentan | (S)-11h | Ki | = | 2.15 | nM | ALA4431783 | 8.67 | nM | Homo sapiens | ||
15. | Bosentan | Bosentan | t1/2 | = | 1 | min | ALA4431776 | hr | Homo sapiens | |||
16. | ALA112624 | 6b | IC50 | = | 0.4 | nM | ALA4431773 | 9.40 | nM | Homo sapiens | ||
17. | Bosentan | Bosentan | IC50 | = | 45 | nM | ALA4431773 | 7.35 | nM | Homo sapiens | ||
18. | Macitentan | MACITENTAN | IC50 | = | 3.4 | nM | ALA4426325 | 8.47 | nM | Homo sapiens | ||
19. | ALA4435789 | 93 | IC50 | = | 29 | nM | ALA4426323 | 7.54 | nM | Homo sapiens | ||
20. | ALA4559129 | 91 | Ki | = | 0.11 | nM | ALA4426323 | 9.96 | nM | Homo sapiens |