| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  BPN14770 | ZATOLMILAST | Activity | 0 | ALA4397272 | Non-Toxic | Mustela putorius furo | |||||
| 2. |  ALA1201770 | METHYLNALTREXONE BROMIDE | ED50 | = | 0.69 | mg kg-1 | ALA4310628 | mg.kg-1 | Mustela putorius furo | |||
| 3. |  ALA2105755 | NALDEMEDINE | ED50 | = | 0.03 | mg kg-1 | ALA4310627 | mg.kg-1 | Mustela putorius furo | |||
| 4. |  ALA3679612 | BDBM102406 | ED50 | = | 0.026 | mg kg-1 | ALA4310627 | mg.kg-1 | Mustela putorius furo | |||
| 5. |  ALA4529950 | 9b | ED50 | = | 0.04 | mg kg-1 | ALA4310627 | mg.kg-1 | Mustela putorius furo | |||
| 6. |  ALA4542825 | 9a | ED50 | = | 0.04 | mg kg-1 | ALA4310627 | mg.kg-1 | Mustela putorius furo | |||
| 7. |  ALA356323 | 1, BRL-61063 | Activity | 0 | ALA3375617 | Toxic | Mustela putorius furo | |||||
| 8. |  ALA3315088 | 20 | MTD | = | 1 | mg kg-1 | ALA3375616 | mg kg-1 | Mustela putorius furo | |||
| 9. | ALA3315088 | 20 | MTD | = | 1 | mg kg-1 | ALA3375615 | mg kg-1 | Mustela putorius furo | |||
| 10. |  ALA3244491 | 16.HCl | Activity | = | -3.2 | % | ALA3255392 | % | Mustela putorius furo | |||
| 11. | ALA3244491 | 16.HCl | Activity | = | -0.4 | % | ALA3255391 | % | Mustela putorius furo | |||
| 12. |  Ribavirin | Ribavirin | Activity | = | -20.1 | % | ALA3255390 | % | Mustela putorius furo | |||
| 13. | ALA3244491 | 16.HCl | Activity | = | -3.3 | % | ALA3255390 | % | Mustela putorius furo | |||
| 14. | Ribavirin | Ribavirin | Activity | = | -22.2 | % | ALA3255389 | % | Mustela putorius furo | |||
| 15. | Ribavirin | Ribavirin | Activity | = | -4.5 | % | ALA3255388 | % | Mustela putorius furo | |||
| 16. |  ALA4074883 | 72 | Activity | 0 | ALA4038080 | Dose-dependent effect | Mustela putorius furo | |||||
| 17. | ALA4074883 | 72 | Activity | 0 | ALA4038079 | Non-Toxic | Mustela putorius furo | |||||
| 18. |  Roflumilast | table 2 Roflumilast (17) | AUC | = | 95 | ng.hr/ml | ALA1833226 | ng.hr.mL-1 | Mustela putorius furo | |||
| 19. |  ALA1830646 | 26 | AUC | = | 13.9 | ng.hr/ml | ALA1833225 | ng.hr.mL-1 | Mustela putorius furo | |||
| 20. | Roflumilast | table 2 Roflumilast (17) | Tmax | = | 4.4 | hr | ALA1833224 | hr | Mustela putorius furo |
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