| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  CCT251545 | 74, CCT251545 | t1/2 | = | 0.7 | hr | ALA3803455 | hr | Canis lupus familiaris | |||
| 2. | CCT251545 | 74, CCT251545 | F | = | 126 | % | ALA3803435 | % | Canis lupus familiaris | |||
| 3. | CCT251545 | 74, CCT251545 | Vd | = | 0.74 | L/Kg | ALA3803434 | L.kg-1 | Canis lupus familiaris | |||
| 4. | CCT251545 | 74, CCT251545 | CLH | = | 33 | % | ALA3803433 | % | Canis lupus familiaris | |||
| 5. | CCT251545 | 74, CCT251545 | CL | = | 0.84 | L/hr/kg | ALA3803428 | mL.min-1.kg-1 | Canis lupus familiaris | |||
| 6. |  CCT-251921 | 109 | t1/2 | = | 0.99 | hr | ALA3803455 | hr | Canis lupus familiaris | |||
| 7. |  (4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one | BDBM9488 | t1/2 | = | 2.2 | hr | ALA3801783 | hr | Canis lupus familiaris | |||
| 8. | (4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one | BDBM9488 | Vdss | = | 3.6 | L/Kg | ALA3801782 | L.kg-1 | Canis lupus familiaris | |||
| 9. | (4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one | BDBM9488 | CL | = | 35 | ml/min.kg | ALA3801581 | mL.min-1.kg-1 | Canis lupus familiaris | |||
| 10. | (4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one | BDBM9488 | F | = | 8.2 | % | ALA3801571 | % | Canis lupus familiaris | |||
| 11. | (4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one | BDBM9488 | Cmax | = | 0.19 | uM | ALA3801570 | nM | Canis lupus familiaris | |||
| 12. | (4aR,7aS)-2-amino-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one | BDBM9488 | AUC | = | 0.39 | uM.hr | ALA3801569 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | Canis lupus familiaris | ||
| 13. |  ALA3794064 | 3; BMS-520 | Ratio | = | 9 | ALA3801340 | Canis lupus familiaris | |||||
| 14. | ALA3794064 | 3; BMS-520 | F | = | 45 | % | ALA3801339 | % | Canis lupus familiaris | |||
| 15. | ALA3794064 | 3; BMS-520 | Vdss | = | 0.7 | L/Kg | ALA3801338 | L.kg-1 | Canis lupus familiaris | |||
| 16. | ALA3794064 | 3; BMS-520 | CL | = | 5.2 | % | ALA3801337 | % | Canis lupus familiaris | |||
| 17. | ALA3794064 | 3; BMS-520 | CL | = | 1.6 | ml/min.kg | ALA3801336 | mL.min-1.kg-1 | Canis lupus familiaris | |||
| 18. | ALA3794064 | 3; BMS-520 | MRT | = | 8.9 | hr | ALA3801335 | hr | Canis lupus familiaris | |||
| 19. | ALA3794064 | 3; BMS-520 | t1/2 | = | 7.4 | hr | ALA3801334 | hr | Canis lupus familiaris | |||
| 20. | ALA3794064 | 3; BMS-520 | AUC | = | 11 | uM.hr | ALA3801333 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | Canis lupus familiaris |
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