| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA2441952 | 2s, BMS-767778, More active atropisomer | Activity | 0 | ALA2445316 | Non-toxic | Canis lupus familiaris | |||||
| 2. | ALA2441952 | 2s, BMS-767778, More active atropisomer | Activity | 0 | ALA2445315 | Toxic | Canis lupus familiaris | |||||
| 3. | ALA2441952 | 2s, BMS-767778, More active atropisomer | Activity | 0 | ALA2444441 | Non-toxic | Canis lupus familiaris | |||||
| 4. |  casopitant | 16a | F | = | 34 | % | ALA2447336 | % | Canis lupus familiaris | |||
| 5. | casopitant | 16a | t1/2 | = | 4.5 | hr | ALA2447338 | hr | Canis lupus familiaris | |||
| 6. | casopitant | 16a | Vdss | = | 1.9 | L/Kg | ALA2447340 | L.kg-1 | Canis lupus familiaris | |||
| 7. | casopitant | 16a | CL | = | 10 | ml/min.kg | ALA2447342 | mL.min-1.kg-1 | Canis lupus familiaris | |||
| 8. |  Orvepitant | ORVEPITANT | Vdss | = | 2 | L/Kg | ALA2447340 | L.kg-1 | Canis lupus familiaris | |||
| 9. |  ALA2441373 | 3c | Vdss | = | 2 | L/Kg | ALA2447340 | L.kg-1 | Canis lupus familiaris | |||
| 10. | ALA2441373 | 3c | t1/2 | = | 5.1 | hr | ALA2447338 | hr | Canis lupus familiaris | |||
| 11. | Orvepitant | ORVEPITANT | CL | = | 6 | ml/min.kg | ALA2447342 | mL.min-1.kg-1 | Canis lupus familiaris | |||
| 12. | Orvepitant | ORVEPITANT | t1/2 | = | 6.1 | hr | ALA2447338 | hr | Canis lupus familiaris | |||
| 13. | ALA2441373 | 3c | CL | = | 11 | ml/min.kg | ALA2447342 | mL.min-1.kg-1 | Canis lupus familiaris | |||
| 14. | ALA2441373 | 3c | F | = | 28 | % | ALA2447336 | % | Canis lupus familiaris | |||
| 15. | Orvepitant | ORVEPITANT | F | = | 55 | % | ALA2447336 | % | Canis lupus familiaris | |||
| 16. | ALA2441952 | 2s, BMS-767778, More active atropisomer | CL | = | 10.6 | ml/min.kg | ALA2444162 | mL.min-1.kg-1 | Canis lupus familiaris | |||
| 17. | ALA2441952 | 2s, BMS-767778, More active atropisomer | Vdss | = | 2.7 | L/Kg | ALA2444158 | L.kg-1 | Canis lupus familiaris | |||
| 18. | ALA2441952 | 2s, BMS-767778, More active atropisomer | t1/2 | = | 7.8 | hr | ALA2444152 | hr | Canis lupus familiaris | |||
| 19. | ALA2441952 | 2s, BMS-767778, More active atropisomer | F | = | 95 | % | ALA2444148 | % | Canis lupus familiaris | |||
| 20. |  GSK2656157 | 6, GSK2656157 | AUC | = | 3128.5 | ng.hr/ml | ALA2443940 | ng.hr.mL-1 | Canis lupus familiaris |
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