| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA2441952 | 2s, BMS-767778, More active atropisomer | CL | = | 19.2 | ml/min.kg | ALA2444160 | mL.min-1.kg-1 | Macaca mulatta | |||
| 2. | ALA2441952 | 2s, BMS-767778, More active atropisomer | Vdss | = | 2.8 | L/Kg | ALA2444156 | L.kg-1 | Macaca mulatta | |||
| 3. | ALA2441952 | 2s, BMS-767778, More active atropisomer | t1/2 | = | 5.6 | hr | ALA2444153 | hr | Macaca mulatta | |||
| 4. | ALA2441952 | 2s, BMS-767778, More active atropisomer | F | = | 84 | % | ALA2444149 | % | Macaca mulatta | |||
| 5. |  ALA2425070 | 23 | Tmax | = | 1.1 | hr | ALA2428778 | hr | Macaca mulatta | |||
| 6. | ALA2425070 | 23 | Cmax | = | 1.48 | uM | ALA2428781 | nM | Macaca mulatta | |||
| 7. | ALA2425070 | 23 | Vdss | = | 4.2 | L/Kg | ALA2428788 | L.kg-1 | Macaca mulatta | |||
| 8. | ALA2425070 | 23 | CL | = | 5.2 | ml/min.kg | ALA2428790 | mL.min-1.kg-1 | Macaca mulatta | |||
| 9. | ALA2425070 | 23 | AUC/dose | = | 7.33 | microM.hr/mg/kg | ALA2428772 | microM.hr/mg/kg | Macaca mulatta | |||
| 10. | ALA2425070 | 23 | beta t1/2 | = | 9.7 | hr | ALA2428784 | hr | Macaca mulatta | |||
| 11. | ALA2425070 | 23 | F | = | 72 | % | ALA2428775 | % | Macaca mulatta | |||
| 12. |  ALA2419745 | LB30870 | F | = | 15 | % | ALA2421905 | % | Macaca mulatta | |||
| 13. |  Tebipenem Pivoxil | TEBIPENEM PIVOXIL | F | = | 35 | % | ALA2415385 | % | Macaca mulatta | |||
| 14. |  5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-piperidin-1-ylpyrimidin-2-yl)pyrazole-4-carboxamide | 33 | Vdss | = | 0.77 | L/Kg | ALA2410907 | L.kg-1 | Macaca mulatta | |||
| 15. | 5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-piperidin-1-ylpyrimidin-2-yl)pyrazole-4-carboxamide | 33 | CL | = | 1 | L/hr/kg | ALA2410908 | mL.min-1.kg-1 | Macaca mulatta | |||
| 16. |  ALA2409024 | 1 | Vdss | = | 1 | L/Kg | ALA2410907 | L.kg-1 | Macaca mulatta | |||
| 17. | 5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-piperidin-1-ylpyrimidin-2-yl)pyrazole-4-carboxamide | 33 | t1/2 | = | 1.2 | hr | ALA2410906 | hr | Macaca mulatta | |||
| 18. | ALA2409024 | 1 | CL | = | 1.3 | L/hr/kg | ALA2410908 | mL.min-1.kg-1 | Macaca mulatta | |||
| 19. | ALA2409024 | 1 | F | = | 3.9 | % | ALA2410905 | % | Macaca mulatta | |||
| 20. | 5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-piperidin-1-ylpyrimidin-2-yl)pyrazole-4-carboxamide | 33 | F | = | 26 | % | ALA2410905 | % | Macaca mulatta |
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