# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-3-(3-propan-2-yloxy-1H-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine | 2c | Selectivity ratio | > | 3800 | ALA2154982 | Homo sapiens | |||||
2. | AZ-23 | 10z | Selectivity ratio | > | 1600 | ALA2154982 | Homo sapiens | |||||
3. | N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-3-(3-propan-2-yloxy-1H-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine | 2c | IC50 | = | 192 | nM | ALA2154981 | 6.72 | nM | Homo sapiens | ||
4. | AZ-23 | 10z | IC50 | = | 2430 | nM | ALA2154981 | 5.61 | nM | Homo sapiens | ||
5. | N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-3-(3-propan-2-yloxy-1H-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine | 2c | IC50 | = | 0.05 | nM | ALA2154980 | 10.30 | nM | Homo sapiens | ||
6. | AZ-23 | 10z | IC50 | = | 1.51 | nM | ALA2154980 | 8.82 | nM | Homo sapiens | ||
7. | ALA4287063 | 5c | IC50 | = | 1.58 | uM | ALA4274059 | 5.80 | nM | Homo sapiens | ||
8. | ALA4280344 | 3i | IC50 | = | 15.11 | uM | ALA4274059 | 4.82 | nM | Homo sapiens | ||
9. | ALA4276920 | 3g | IC50 | = | 1.1 | uM | ALA4274059 | 5.96 | nM | Homo sapiens | ||
10. | ALA4288543 | 3e | IC50 | > | 60 | uM | ALA4274059 | nM | Homo sapiens | |||
11. | ALA53463 | Adriamycin | IC50 | = | 1.54 | uM | ALA4274034 | 5.81 | nM | Homo sapiens | ||
12. | ALA4288267 | 5i | IC50 | = | 14.66 | uM | ALA4274034 | 4.83 | nM | Homo sapiens | ||
13. | ALA4281455 | 5e | IC50 | = | 18.93 | uM | ALA4274034 | 4.72 | nM | Homo sapiens | ||
14. | ALA4287063 | 5c | IC50 | = | 18.87 | uM | ALA4274034 | 4.72 | nM | Homo sapiens | ||
15. | ALA4283805 | 3k | IC50 | = | 6.52 | uM | ALA4274034 | 5.19 | nM | Homo sapiens | ||
16. | ALA4280344 | 3i | IC50 | = | 29.26 | uM | ALA4274034 | 4.53 | nM | Homo sapiens | ||
17. | ALA4276920 | 3g | IC50 | = | 24.25 | uM | ALA4274034 | 4.62 | nM | Homo sapiens | ||
18. | ALA4288543 | 3e | IC50 | = | 40.64 | uM | ALA4274034 | 4.39 | nM | Homo sapiens | ||
19. | ALA4278703 | 3b | IC50 | = | 12.11 | uM | ALA4274034 | 4.92 | nM | Homo sapiens | ||
20. | ALA4286616 | 3a | Activity | = | 34.4 | % | ALA4274030 | % | Homo sapiens |