| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  (2R)-N-[(2S)-1-[(4-carbamimidoylphenyl)methylamino]-3-hydroxy-1-oxopropan-2-yl]-3-hydroxy-2-(phenylmethylsulfonylamino)propanamide | 4 | TGI | = | 43 | % | ALA4424448 | % | Mus musculus | |||
| 2. | (2R)-N-[(2S)-1-[(4-carbamimidoylphenyl)methylamino]-3-hydroxy-1-oxopropan-2-yl]-3-hydroxy-2-(phenylmethylsulfonylamino)propanamide | 4 | Activity | = | 41.5 | % | ALA4424444 | % | Mus musculus | |||
| 3. |  ALA4435851 | 23a | Activity | 0 | ALA4409514 | Active | Mus musculus | |||||
| 4. | ALA4435851 | 23a | Activity | 0 | ALA4409513 | Active | Mus musculus | |||||
| 5. | ALA4435851 | 23a | Activity | 0 | ALA4409512 | Active | Mus musculus | |||||
| 6. | ALA4435851 | 23a | Activity | 0 | ALA4409511 | Active | Mus musculus | |||||
| 7. |  Epacadostat (INCB024360) | EPACADOSTAT | Activity | = | 21 | ALA4408574 | Mus musculus | |||||
| 8. | Epacadostat (INCB024360) | EPACADOSTAT | INH | = | 77 | % | ALA4408575 | % | Mus musculus | |||
| 9. |  ALA4514196 | 16 | INH | = | 77 | % | ALA4408575 | % | Mus musculus | |||
| 10. | ALA4514196 | 16 | Activity | = | 21 | ALA4408574 | Mus musculus | |||||
| 11. | ALA4514196 | 16 | Activity | 0 | ALA4408573 | Active | Mus musculus | |||||
| 12. | ALA4514196 | 16 | INH | 0 | ALA4408572 | Dose-dependent effect | % | Mus musculus | ||||
| 13. | Epacadostat (INCB024360) | EPACADOSTAT | Activity | 0 | ALA4408571 | Active | Mus musculus | |||||
| 14. | ALA4514196 | 16 | Activity | 0 | ALA4408570 | Active | Mus musculus | |||||
| 15. |  ALA4437046 | 5a | Activity | 0 | ALA4356160 | Not Active | Mus musculus | |||||
| 16. |  1-Methyl-L-tryptophan | 1-methyltryptophan | Activity | = | 33.6 | % | ALA4356159 | % | Mus musculus | |||
| 17. | ALA4437046 | 5a | Activity | = | 56.2 | % | ALA4356158 | % | Mus musculus | |||
| 18. | 1-Methyl-L-tryptophan | 1-methyltryptophan | Activity | 0 | ALA4356157 | Active | Mus musculus | |||||
| 19. | ALA4437046 | 5a | Activity | 0 | ALA4356156 | Active | Mus musculus | |||||
| 20. |  ALA1668229 | 6m | IC50 | = | 6.5 | uM | ALA4348043 | 5.19 | nM | Mus musculus |
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