| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2071962 | A | Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins | Homo sapiens | 221 | ALA2069259 | single protein format | Scientific Literature | |
| 2. | ALA2071963 | A | Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins | Homo sapiens | 221 | ALA2069259 | single protein format | Scientific Literature | |
| 3. | ALA2071964 | A | Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins | Homo sapiens | 221 | ALA2069259 | single protein format | Scientific Literature | |
| 4. | ALA2071965 | A | Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins | Homo sapiens | 221 | ALA2069259 | single protein format | Scientific Literature | |
| 5. | ALA2071966 | A | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins | Homo sapiens | 221 | ALA2069259 | single protein format | Scientific Literature | |
| 6. | ALA2071967 | A | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins | Homo sapiens | 221 | ALA2069259 | single protein format | Scientific Literature | |
| 7. | ALA2071971 | A | Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis | Homo sapiens | 107 | ALA2069259 | microsome format | Scientific Literature | |
| 8. | ALA2071972 | A | Covalent binding affinity to human liver microsomes assessed per mg of protein at 10 uM after 60 mins presence of NADPH | Homo sapiens | 221 | ALA2069259 | microsome format | Scientific Literature | |
| 9. | ALA2427052 | A | Cellular uptake in human HEK293 cells assessed as human OCT2-mediated drug transport at 2.5 uM after 4 mins by LC-MS/MS analysis relative to passive uptake | Homo sapiens | 24 | ALA2424515 | cell-based format | Scientific Literature | |
| 10. | ALA2427053 | A | Cellular uptake in human HEK293 cells assessed as human OCT1-mediated drug transport at 2.5 uM after 4 mins by LC-MS/MS analysis relative to passive uptake | Homo sapiens | 24 | ALA2424515 | cell-based format | Scientific Literature | |
| 11. | ALA2427054 | A | Cellular uptake in human HEK293 cells assessed as human OCT2-mediated drug transport at 2.5 uM after 4 mins by LC-MS/MS analysis | Homo sapiens | 24 | ALA2424515 | cell-based format | Scientific Literature | |
| 12. | ALA2427055 | A | Cellular uptake in human HEK293 cells assessed as human OCT1-mediated drug transport at 2.5 uM after 4 mins by LC-MS/MS analysis | Homo sapiens | 24 | ALA2424515 | cell-based format | Scientific Literature | |
| 13. | ALA2427814 | A | Cellular uptake in human HEK293 cells assessed as human OCT1-mediated drug transport after 4 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA2424515 | cell-based format | Scientific Literature | |
| 14. | ALA3630582 | B | Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M3 receptor assessed as compound dissociation half life by dilution method | Homo sapiens | 12 | ALA3627605 | single protein format | Scientific Literature | |
| 15. | ALA3630589 | B | Activity at beta2 adrenoceptor/muscarinic M3 receptor in guinea pig trachea assessed as inhibition of electric fileld-stimulated contraction | Cavia porcellus | 3 | ALA3627605 | assay format | Scientific Literature | |
| 16. | ALA3630591 | B | Activity at beta2 adrenoceptor/muscarinic M3 receptor in guinea pig trachea assessed as time required for inhibited electric fileld-stimulated contraction to recover by 25% | Cavia porcellus | 3 | ALA3627605 | assay format | Scientific Literature | |
| 17. | ALA3630594 | F | Bronchodilator activity in intratracheally dosed conscious dog assessed as inhibition of methacholine-induced bronchoconstriction administered in micelle solution | Canis lupus familiaris | 3 | ALA3627605 | organism-based format | Scientific Literature | |
| 18. | ALA3630595 | F | Bronchodilator activity in conscious dog assessed as time required to inhibit methacholine-induced bronchoconstriction at 30 ug administered through intratracheally in micelle solution | Canis lupus familiaris | 3 | ALA3627605 | organism-based format | Scientific Literature | |
| 19. | ALA4303810 | F | Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HRCE cells at MOI 0.4 after 96 hrs (reported as hit score from 0-1 for on-disease vs off-disease activity: scores >0.6 considered hits) | Homo sapiens | 1,629 | ALA4303122 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
| 20. | ALA5034532 | B | Displacement of [3H]-N-methyl Scopolamine Chloride from human M3 receptor membranes incubated for 2 hrs by scintillation counting analysis | Homo sapiens | 36 | ALA5034004 | cell membrane format | Scientific Literature |
The page will load shortly, Thanks for your patience!