| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1634716 | A | Cytotoxicity against human HeLa cells 10 uM after 24 hrs by MTS assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA1634717 | A | Cytotoxicity against human HeLa cells at 10 uM by MTS assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA1634721 | F | Antiviral activity against Human poliovirus type 1 infected in Human HeLa cell assessed as log reduction in viral titer at 10 uM administered 6 hrs before infection measured after 10 hrs post infection by plaque assay | Poliovirus 1 | 8 | organism-based format | Scientific Literature | ||
| 4. | ALA1634722 | F | Antiviral activity against Human poliovirus type 1 infected in Human HeLa cell after 21 hrs post infection by plaque assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA1634723 | F | Cytotoxicity against human HeLa cell after 21 hrs by MTS assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA1634724 | F | Selectivity index, Ratio of CC50 for human HeLa cell to IC50 for Human poliovirus type 1 | 1 | cell-based format | Scientific Literature | |||
| 7. | ALA1634725 | F | Antiviral activity against Human poliovirus type 1 infected in Human HeLa cell assessed as inhibition of translation at 10 uM by luciferase reporter gene assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA1634726 | F | Antiviral activity against Human poliovirus type 1 infected in Human HeLa cell assessed as inhibition of translation at 10 ug/ml by luciferase reporter gene assay | Poliovirus 1 | 9 | organism-based format | Scientific Literature | ||
| 9. | ALA1634728 | F | Antiviral activity against Human poliovirus type 1 infected in Human HeLa cell selected after 12 passages in presence of 5 to 10 uM of compound | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA1634729 | F | Antiviral activity against Human poliovirus type 1 harboring U4 substitution in the PPMO target region infected in Human HeLa cell at 10 uM | Poliovirus 1 | 8 | organism-based format | Scientific Literature | ||
| 11. | ALA1634730 | F | Antiviral activity against Human poliovirus type 1 harboring A18 substitution in the PPMO target region infected in Human HeLa cell at 10 uM | Poliovirus 1 | 8 | organism-based format | Scientific Literature | ||
| 12. | ALA1634731 | F | Antiviral activity against Human poliovirus type 1 harboring A18 and U4 double mutation in the PPMO target region infected in Human HeLa cell at 10 uM | Poliovirus 1 | 8 | organism-based format | Scientific Literature | ||
| 13. | ALA1634732 | F | Antiviral activity against Human poliovirus type 1 infected in mouse assessed as viral titer in small intestine at 10 mg/kg, ip administered 1 hr post infection once daily for 5 days measured after 8 days by plaque assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA1634733 | F | Antiviral activity against Human poliovirus type 1 infected in mouse assessed as viral titer in small intestine at 10 mg/kg, ip administered 1 hr post infection once daily for 5 days measured after 7 days by plaque assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA1634734 | F | Antiviral activity against Human poliovirus type 1 infected in mouse assessed as viral titer in small intestine at 10 mg/kg, ip administered 1 hr post infection once daily for 5 days measured after 10 days by plaque assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA1634735 | F | Antiviral activity against Human poliovirus type 1 infected in mouse assessed as viral titer in spinal cord at 10 mg/kg, ip administered 1 hr post infection once daily for 5 days measured after 8 days by plaque assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA1634736 | F | Antiviral activity against Human poliovirus type 1 infected in mouse assessed as viral titer in spinal cord at 10 mg/kg, ip administered 1 hr post infection once daily for 5 days measured after 7 days by plaque assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA1634737 | F | Antiviral activity against Human poliovirus type 1 infected in mouse assessed as viral titer in spinal cord at 10 mg/kg, ip administered 1 hr post infection once daily for 5 days measured after 10 days by plaque assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA1634738 | F | Antiviral activity against Human poliovirus type 1 infected in mouse assessed as viral titer in brain 10 mg/kg, ip administered 1 hr post infection once daily for 5 days measured after 8 days by plaque assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA1634739 | F | Antiviral activity against Human poliovirus type 1 infected in mouse assessed as viral titer in brain at 10 mg/kg, ip administered 1 hr post infection once daily for 5 days measured after 7 days by plaque assay | Poliovirus 1 | 1 | organism-based format | Scientific Literature |
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