| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1653515 | F | Antitrypanosomal activity against wild-type Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as cure from infection at 25 mg/kg, po for 4 days | Trypanosoma brucei rhodesiense | 5 | organism-based format | Scientific Literature | ||
| 2. | ALA1653518 | F | Antitrypanosomal activity against wild-type Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as survival of mouse at 25 mg/kg, po for 4 days | Trypanosoma brucei rhodesiense | 6 | organism-based format | Scientific Literature | ||
| 3. | ALA1653519 | F | Antitrypanosomal activity against wild-type Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as survival of mouse at 5 mg/kg, po for 4 days | Trypanosoma brucei rhodesiense | 5 | organism-based format | Scientific Literature | ||
| 4. | ALA1654298 | F | Antitrypanosomal activity against Trypanosoma brucei brucei GVR35 infected in NMRI mouse CNS model assessed as survival of mouse at 100 mg/kg, po for 5 days | Trypanosoma brucei brucei | 6 | organism-based format | Scientific Literature | ||
| 5. | ALA1654309 | F | Antitrypanosomal activity against wild-type Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as cure from infection at 5 mg/kg, po for 4 days | Trypanosoma brucei rhodesiense | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA3539595 | A | Prodrug conversion in human liver microsomes assessed as elution time treated with 10 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 7. | ALA3536991 | A | Drug level in human liver microsomes treated with 10 uM DB868 prodrug after 180 mins incubation by HPLC-UV chromatography relative to initial prodrug concentration | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 8. | ALA3536992 | A | Drug level in rat liver microsomes treated with 10 uM DB868 prodrug after 180 mins incubation by HPLC-UV chromatography relative to initial prodrug concentration | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 9. | ALA3536993 | A | Activity at human recombinant CYP4F2-mediated drug metabolism treated with 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3537360 | A | Activity at human recombinant CYP1A2-mediated drug metabolism treated with 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA3537361 | A | Activity at human recombinant CYP3A4-mediated drug metabolism treated with 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3537366 | A | Drug metabolism in rat recombinant CYP1A2 treated with at 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 13. | ALA3537367 | A | Drug metabolism in rat recombinant CYP3A4 treated with at 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 14. | ALA3536461 | A | Drug metabolism in sandwich-cultured human hepatocytes treated with 10 uM DB868 after 4 hrs of incubation by HPLC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA3536462 | A | Drug metabolism in sandwich-cultured rat hepatocytes treated with 10 uM DB868 after 4 hrs of incubation by HPLC-MS/MS analysis | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA3536857 | A | Drug metabolism in human liver microsomes assessed as (3Z,3'Z)-6,6'-(furan-2,5-diyl)bis(N'-hydroxynicotinimidamide) formation measured per mg of protein by HPLC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA3536858 | A | Drug metabolism in human liver microsomes assessed as (3Z,3'Z)-6,6'-(furan-2,5-diyl)bis(N'-hydroxynicotinimidamide) formation measured by HPLC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA3536863 | A | Prodrug conversion in rat liver microsomes assessed as elution time treated with 10 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Rattus norvegicus | 4 | assay format | Scientific Literature | ||
| 19. | ALA3530765 | A | Drug metabolism in rat recombinant CYP4F2 treated with at 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Rattus norvegicus | 1 | assay format | Scientific Literature |
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