| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1659755 | F | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as complete cure from microbial infection at 2 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 11 | organism-based format | Scientific Literature | ||
| 2. | ALA1659756 | F | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 2 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 17 | organism-based format | Scientific Literature | ||
| 3. | ALA4814081 | F | Cytotoxicity against mouse MigA9 cells harboring mouse Hoxa9 gene incubated for 72 hrs by MTS assay | Mus musculus | 10 | cell-based format | Scientific Literature | ||
| 4. | ALA4814082 | A | Drug localization in nucleus of human HT-29 cells at 5 uM incubated for 16 hrs by DiOC6/propidium iodide staining based by fluorescence microscopy | Homo sapiens | 7 | subcellular format | Scientific Literature | ||
| 5. | ALA4814083 | B | Inhibition of HOXA9 (unknown origin) expressed in reticulocyte lysate system binding to DNA Hoxa9-binding site (5'-biotin-cctctcctctcctGCGATGATTTACGACCGC) (unknown origin) assessed as Hoxa9/DNA remaining complexes at 5 to 10 uM incubated for 20 mins with DNA followed by compound wash out and subsequent HOXA9 addition and measured after 1 hr by ELISA | 39 | subcellular format | Scientific Literature | |||
| 6. | ALA4814087 | B | Inhibition of HOXA9 (unknown origin) expressed in reticulocyte lysate system binding to 32P-radiolabeled DNA Hoxa9-binding site (strand a-CTGCGATGATTTACGACCGC /strand b-GCGGTCGTAAATCATCGCAG) (unknown origin) assessed as HOXA9/DNA inhibition at 2.5 to 20 uM incubated for 20 mins by electrophoretic mobility shift assay relative to control | 9 | subcellular format | Scientific Literature | |||
| 7. | ALA4814092 | B | Binding affinity to DNA Hoxa9-binding site (strand a-CTGCGATGATTTACGACCGC/strand b-GCGGTCGTAAATCATCGCAG) (unknown origin) assessed as compound-DNA complex formation at 1 to 10 uM at wavelength of 300 to 400 nM by circular dichroism method | Not specified | 9 | nucleic acid format | Scientific Literature | ||
| 8. | ALA4814093 | B | Binding affinity to DNA Hoxa9-binding site (strand a-CTGCGATGATTTACGACCGC/strand b-GCGGTCGTAAATCATCGCAG) (unknown origin) assessed as change in positive ellipticity band of the DNA helix at 1 to 10 uM at wavelength of 300 to 400 nM by circular dichroism method | Not specified | 9 | nucleic acid format | Scientific Literature | ||
| 9. | ALA4814095 | B | Binding affinity to DNA FP-Hoxa9 binding site-1R (strand a-cgcgGTTCCTCTGATCGCGGACCACCGACAGCTGCGATGATTTACGACCGCGCTCGAACCTGAACCTGATCTCAAGTGCT/strand b-ctagAGCACTTGAGATCAGGTTCAGGTTCGAGCGCGGTCGTAAATCATCGCAGCTGTCGGTGGTCCGCGATCAGAGGAAC) (unknown origin) assessed as recognition of HOXA9 binding site 5'-ATTTA at 0.5 to 1.5 uM by DNase1footprinting based densitometric analysis | Not specified | 4 | nucleic acid format | Scientific Literature | ||
| 10. | ALA4814096 | B | Binding affinity to DNA Hoxa9 binding site-5'ATGA mutant (strand a-CTGCGTAGATTTACGACCGC/strand b-GCGGTCGTAAATCTACGCAG) (unknown origin) by UV/visible spectrophotometric method | Not specified | 3 | nucleic acid format | Scientific Literature | ||
| 11. | ALA4814099 | B | Binding affinity to DNA Hoxa9-binding site-5'-ATTTA mutant (strand a-CTGCGATGAGTCACGACCGC/strand b-GCGGTCGTGACTCATCGCAG) (unknown origin) by UV/visible spectrophotometric method | Not specified | 1 | nucleic acid format | Scientific Literature | ||
| 12. | ALA4814100 | B | Binding affinity to DNA Hoxa9-binding site-5'-ATTTA/5'ATGA double mutant (strand a-CTGCGTAGCGTCACGACCGC/strand b-GCGGTCGTGACGCTACGCAG) (unknown origin) by UV/visible spectrophotometric method | Not specified | 1 | nucleic acid format | Scientific Literature | ||
| 13. | ALA4814107 | F | Induction of cell death in mouse MigA9 cells harboring mouse Hoxa9 gene assessed as propidium iodide-positive cells at 15 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 9.06 +/- 0.53%) | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 14. | ALA4814108 | F | Induction of cell death in mouse MigA9 cells harboring mouse Hoxa9 gene assessed as propidium iodide-positive cells at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 9.06 +/- 0.53%) | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA4814113 | F | Induction of cell death in mouse MigA9 cells harboring mouse Hoxa9 gene assessed as propidium iodide-positive cells at 15 uM incubated for 48 hrs by propidium iodide staining based flow cytometry (Rvb = 8.75 +/- 0.2%) | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 16. | ALA4814114 | F | Induction of cell death in mouse MigA9 cells harboring mouse Hoxa9 gene assessed as propidium iodide-positive cells at 20 uM incubated for 48 hrs by propidium iodide staining based flow cytometry (Rvb = 8.75 +/- 0.2%) | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 17. | ALA4814119 | F | Induction of cell cycle arrest in mouse MigA9 cells harboring mouse Hoxa9 gene assessed as accumulation at sub-G1 phase at 15 uM incubated for 48 hrs by propidium iodide staining based flow cytometry (Rvb = 0.76 +/- 0.1%) | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA4814120 | F | Induction of cell cycle arrest in mouse MigA9 cells harboring mouse Hoxa9 gene assessed as accumulation at sub-G1 phase at 20 uM incubated for 48 hrs by propidium iodide staining based flow cytometry (Rvb = 0.76 +/- 0.1%) | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 19. | ALA4814125 | B | Inhibition of transactivation domain fused HOXA9 (unknown orgin) interaction with Luc-tagged DNA HOXA9 binding site (strand a-cgcgGTTCTCGATGATTTACGGATGATTTACTGATGATTTACCGATGATTTACAGATGATTTACGGATGATTTACGTGCT/strand b-ctagAGCACGTAAATCATCCGTAAATCATCTGTAAATCATCGGTAAATCATCAGTAAATCATCCGTAAATCATCGAGAAC) (unknown origin) co-transfected in human K562 cells assessed as reduction in HOXA9-mediated transactivation at 20 uM incubated for 48 hrs by luciferase assay | 3 | cell-based format | Scientific Literature | |||
| 20. | ALA4814126 | B | Inhibition of transactivation domain fused HOXA9 (unknown orgin) interaction with Luc-tagged DNA HOXA9 binding site mutant (strand a-cgcgGTTCTCGATGCTGTCCGGATGCTGTCCTGATGCTGTCCCGATGCTGTCCAGATGCTGTCCGGATGCTGTCCGTGCT/strand b-ctagAGCACGGACAGCATCCGGACAGCATCTGGACAGCATCGGGACAGCATCAGGACAGCATCCGGACAGCATCGAGAAC) (unknown origin) co-transfected in human K562 cells assessed as reduction in HOXA9-mediated transactivation at 20 uM incubated for 48 hrs by luciferase assay | 3 | cell-based format | Scientific Literature |
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