# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1659755 | Functional | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as complete cure from microbial infection at 2 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 11 | ALA1649292 | organism-based format | Scientific Literature | |
2. | ALA1659756 | Functional | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 2 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 17 | ALA1649292 | organism-based format | Scientific Literature | |
3. | ALA1659761 | Functional | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 0.125 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 7 | ALA1649292 | organism-based format | Scientific Literature | |
4. | ALA1660231 | Functional | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 0.5 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 21 | ALA1649292 | organism-based format | Scientific Literature | |
5. | ALA1660232 | Functional | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 0.25 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 9 | ALA1649292 | organism-based format | Scientific Literature | |
6. | ALA1660236 | Functional | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as complete cure from microbial infection at 0.5 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 14 | ALA1649292 | organism-based format | Scientific Literature | |
7. | ALA4005806 | Binding | Binding affinity to poly(dA-dT)n DNA (unknown origin) assessed as change in melting temperature at 0.3 molar ratio of compound:DNA by spectrophotometric analysis | Not specified | 13 | ALA4004827 | assay format | Scientific Literature | |
8. | ALA4005809 | ADME | Cytotoxicity against rat L6 cells | Rattus norvegicus | 13 | ALA4004827 | cell-based format | Scientific Literature | |
9. | ALA4005810 | Functional | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 bloodstream forms after 70 hrs by Alamar blue assay | Trypanosoma brucei rhodesiense | 13 | ALA4004827 | assay format | Scientific Literature | |
10. | ALA4005811 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900 bloodstream forms | 13 | ALA4004827 | assay format | Scientific Literature | ||
11. | ALA4005812 | Functional | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as aparasitemic mouse at 5 mg/kg, ip for 4 consecutive days starting from day 3 post infection measured up to day 60 post infection relative to control | Trypanosoma brucei rhodesiense | 10 | ALA4004827 | organism-based format | Scientific Literature | |
12. | ALA4005814 | Functional | Potency index, ratio of DAPI IC50 to compound IC50 for Trypanosoma brucei rhodesiense STIB900 bloodstream forms | Trypanosoma brucei rhodesiense | 10 | ALA4004827 | assay format | Scientific Literature |