# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1656917 | B | Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay | Mus musculus | 26 | ALA1649099 | cell-based format | Scientific Literature | |
2. | ALA1656918 | B | Inhibition of recombinant GBA1 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay | 26 | ALA1649099 | single protein format | Scientific Literature | ||
3. | ALA1656919 | B | Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay | 26 | ALA1649099 | single protein format | Scientific Literature | ||
4. | ALA1656920 | B | Inhibition of sucrase in mouse intestinal input by glucose release assay | Mus musculus | 26 | ALA1649099 | single protein format | Scientific Literature | |
5. | ALA1656921 | B | Inhibition of lactase in mouse intestinal input by glucose release assay | Mus musculus | 26 | ALA1649099 | single protein format | Scientific Literature | |
6. | ALA1656922 | B | Inhibition of maltase in mouse intestinal input by glucose release assay | Mus musculus | 26 | ALA1649099 | single protein format | Scientific Literature | |
7. | ALA1656923 | B | Selectivity index, ratio of IC50 for recombinant GBA1 to IC50 for glucosylceramide synthase in mouse RAW cells | 26 | ALA1649099 | cell-based format | Scientific Literature | ||
8. | ALA4395491 | B | Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay | Homo sapiens | 15 | ALA4393698 | cell-based format | Scientific Literature | |
9. | ALA4395492 | B | Inhibition of GCase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay relative to control | Homo sapiens | 15 | ALA4393698 | cell-based format | Scientific Literature | |
10. | ALA4395493 | B | Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay | Homo sapiens | 15 | ALA4393698 | cell-based format | Scientific Literature | |
11. | ALA4395494 | B | Inhibition of NLGase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay relative to control | Homo sapiens | 15 | ALA4393698 | cell-based format | Scientific Literature |