| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2044568 | F | Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO-NFAT cells assessed as potentiation of acetylcholine-induced calcium flux after 1 hr by FLIPR assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 2. | ALA2044569 | F | Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO-NFAT cells assessed as potentiation of acetylcholine-induced calcium flux after 1 hr by FLIPR assay relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 3. | ALA2044570 | A | Protein binding in rat plasma | Rattus norvegicus | 10 | cell-free format | Scientific Literature | ||
| 4. | ALA2044571 | A | Protein binding in human plasma | Homo sapiens | 10 | cell-free format | Scientific Literature | ||
| 5. | ALA2044574 | A | Passive permeability of the compound assessed as P-glycoprotein-mediated drug transport | 4 | assay format | Scientific Literature | |||
| 6. | ALA2044575 | A | Efflux ratio of the compound assessed as ratio of human MDR1-mediated permeability from basolateral to apical over apical to basolateral side of drug transport | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 7. | ALA2044576 | A | Efflux ratio of the compound assessed as ratio of rat MDR1a-mediated permeability from basolateral to apical over apical to basolateral side of drug transport | Rattus norvegicus | 3 | single protein format | Scientific Literature | ||
| 8. | ALA2044577 | A | Plasma concentration in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 9. | ALA2044726 | A | Drug uptake in Sprague-Dawley rat brain at 10 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 10. | ALA2044727 | A | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 11. | ALA2044728 | A | Drug uptake in Sprague-Dawley rat cerebrospinal fluid at 10 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 12. | ALA2044729 | A | Ratio of drug uptake in Sprague-Dawley rat cerebrospinal fluid at 10 mg/kg, po to protein binding in rat plasma | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 13. | ALA2044730 | B | Inhibition of human ERG | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 14. | ALA2044731 | F | Agonist activity at human muscarinic M1 receptor expressed in CHO-NFAT cells assessed as effect on calcium flux up to 10 uM after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA2044732 | F | Agonist activity at human muscarinic M2 receptor expressed in CHO-NFAT cells assessed as potentiation of acetylcholine-induced calcium flux at up to 100 uM after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA2044733 | F | Agonist activity at human muscarinic M3 receptor expressed in CHO-NFAT cells assessed as potentiation of acetylcholine-induced calcium flux at up to 100 uM after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA2044734 | F | Agonist activity at human muscarinic M4 receptor expressed in CHO-NFAT cells assessed as potentiation of acetylcholine-induced calcium flux at up to 100 uM after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA2044735 | F | Antagonist activity at human muscarinic M2 receptor expressed in CHO-NFAT cells assessed as inhibition of acetylcholine-induced calcium flux at up to 100 uM after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA2044736 | F | Antagonist activity at human muscarinic M3 receptor expressed in CHO-NFAT cells assessed as inhibition of acetylcholine-induced calcium flux at up to 100 uM after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA2044737 | F | Antagonist activity at human muscarinic M4 receptor expressed in CHO-NFAT cells assessed as inhibition of acetylcholine-induced calcium flux at up to 100 uM after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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