| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1696021 | F | Agonist activity at RXRalpha transfected in human COS1 cells after 18 hrs by luciferase reporter gene transactivation assay | 15 | ALA1687703 | cell-based format | Scientific Literature | ||
| 2. | ALA1696022 | F | Agonist activity at RXRalpha transfected in human COS1 cells at 1 uM after 18 hrs by luciferase reporter gene transactivation assay relative to LGD1069 | 15 | ALA1687703 | cell-based format | Scientific Literature | ||
| 3. | ALA1696023 | F | Agonist activity at PPARgamma transfected in human COS1 cells after 18 hrs by luciferase reporter gene transactivation assay | 3 | ALA1687703 | cell-based format | Scientific Literature | ||
| 4. | ALA1696024 | F | Agonist activity at LXRalpha transfected in human COS1 cells after 18 hrs by luciferase reporter gene transactivation assay | 3 | ALA1687703 | cell-based format | Scientific Literature | ||
| 5. | ALA1696025 | F | Agonist activity at RXRalpha transfected in human COS1 cells at 10'-7 to 10'-6 M after 18 hrs by luciferase reporter gene transactivation assay | 3 | ALA1687703 | cell-based format | Scientific Literature | ||
| 6. | ALA1696526 | F | Agonist activity at PPARgamma/RXRalpha transfected in human COS1 cells at 10'-7 to 10'-6 M after 18 hrs by luciferase reporter gene transactivation assay | 2 | ALA1687703 | cell-based format | Scientific Literature | ||
| 7. | ALA2032538 | F | Agonist activity at RXRalpha transfected in human COS1 cells after 18 hrs by luciferase reporter gene transactivation assay relative to LGD1069 | Homo sapiens | 5 | ALA2029300 | cell-based format | Scientific Literature | |
| 8. | ALA3429522 | B | Agonist activity at RXRalpha (unknown origin) expressed in COS1 cells incubated for 18 hrs by luciferase reporter gene assay | Homo sapiens | 5 | ALA3425461 | cell-based format | Scientific Literature | |
| 9. | ALA3429523 | B | Agonist activity at RXRalpha (unknown origin) expressed in COS1 cells incubated for 18 hrs by luciferase reporter gene assay relative to 1 uM bexarotene | Homo sapiens | 4 | ALA3425461 | cell-based format | Scientific Literature | |
| 10. | ALA3429525 | A | AUC in mouse blood at 30 mg/kg, po | Mus musculus | 2 | ALA3425461 | organism-based format | Scientific Literature | |
| 11. | ALA3429526 | P | Retention time of the compound by HPLC method | 4 | ALA3425461 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA3430139 | A | Drug level in ICR mouse plasma at 30 mg/kg, po administered as single dose measured after 1 hr | Mus musculus | 3 | ALA3425461 | organism-based format | Scientific Literature | |
| 13. | ALA3430140 | A | Drug level in ICR mouse brain at 30 mg/kg, po administered as single dose measured after 1 hr | Mus musculus | 3 | ALA3425461 | organism-based format | Scientific Literature | |
| 14. | ALA3430141 | A | Ratio of drug level in brain to plasma of ICR mouse at 30 mg/kg, po administered as single dose measured after 1 hr | Mus musculus | 3 | ALA3425461 | organism-based format | Scientific Literature | |
| 15. | ALA4415455 | B | Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assay | Homo sapiens | 6 | ALA4414573 | single protein format | Scientific Literature | |
| 16. | ALA5258380 | B | Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant using SRC1 as coactivator peptide by isothermal titration calorimetry analysis | Homo sapiens | 3 | ALA5257054 | assay format | Scientific Literature | |
| 17. | ALA5258381 | B | Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant using PGC-1alpha as coactivator peptide by isothermal titration calorimetry analysis | Homo sapiens | 3 | ALA5257054 | assay format | Scientific Literature | |
| 18. | ALA5258382 | B | Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as gibbs free energy change using SRC1 as coactivator peptide by isothermal titration calorimetry analysis | Homo sapiens | 3 | ALA5257054 | assay format | Scientific Literature | |
| 19. | ALA5258383 | B | Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as gibbs free energy change using PGC-1alpha as coactivator peptide by isothermal titration calorimetry analysis | Homo sapiens | 3 | ALA5257054 | assay format | Scientific Literature | |
| 20. | ALA5258384 | B | Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as change in enthalpy using SRC1 as coactivator peptide by isothermal titration calorimetry analysis | Homo sapiens | 3 | ALA5257054 | assay format | Scientific Literature |
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