| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1697031 | B | Inhibition of Clostridium botulinum BoNT/A-mediated neuromuscular block in CD1 mouse phrenic nerve hemidiaphragm assessed as time required to 50% loss of twitch tension at 10 uM after 15 to 20 mins | Clostridium botulinum | 2 | ALA1687736 | single protein format | Scientific Literature | |
| 2. | ALA1697033 | B | Inhibition of zinc carboxypeptidase A at up to 20 uM | 5 | ALA1687736 | assay format | Scientific Literature | ||
| 3. | ALA1697034 | B | Inhibition of Clostridium botulinum BoNT/A light chain-mediated SNAP-25 cleavage in mouse Neuro2a cells at 10 uM after 30 mins by Western blotting | Clostridium botulinum | 5 | ALA1687736 | cell-based format | Scientific Literature | |
| 4. | ALA1697035 | B | Inhibition of Clostridium botulinum BoNT/A light chain-mediated SNAP-25 cleavage in mouse Neuro2a cells at 15 uM after 30 mins by Western blotting | Clostridium botulinum | 5 | ALA1687736 | cell-based format | Scientific Literature | |
| 5. | ALA1697036 | B | Inhibition of protease activity of recombinant full-length Clostridium botulinum BoNT/A light chain at 200 uM after 5 mins by HPLC-based assay | Clostridium botulinum | 12 | ALA1687736 | single protein format | Scientific Literature | |
| 6. | ALA1697038 | B | Inhibition of protease activity of recombinant full-length Clostridium botulinum BoNT/B light chain at 20 uM after 5 mins by HPLC-based assay | Clostridium botulinum | 5 | ALA1687736 | single protein format | Scientific Literature | |
| 7. | ALA1697040 | B | Inhibition of protease activity of recombinant full-length Clostridium botulinum BoNT/A light chain after 5 mins by HPLC-based assay | Clostridium botulinum | 5 | ALA1687736 | single protein format | Scientific Literature | |
| 8. | ALA1697041 | B | Inhibition of protease activity of recombinant Clostridium botulinum BoNT/A (1 to 425) light chain after 5 mins by HPLC-based assay | Clostridium botulinum | 5 | ALA1687736 | single protein format | Scientific Literature | |
| 9. | ALA1697042 | B | Inhibition of protease activity of recombinant Clostridium botulinum BoNT/E light chain expressed in Escherichia coli (pET24a+/BL21(DE3)) assessed as cleavage of SNAP-25 at 240 uM after 30 mins by SDS-PAGE analysis | Clostridium botulinum | 5 | ALA1687736 | assay format | Scientific Literature | |
| 10. | ALA1794424 | F | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | 30,565 | ALA1201862 | assay format | PubChem BioAssays | ||
| 11. | ALA1794483 | F | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | 114,923 | ALA1201862 | assay format | PubChem BioAssays | ||
| 12. | ALA1794553 | F | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | Homo sapiens | 58,172 | ALA1201862 | cell-based format | PubChem BioAssays | |
| 13. | ALA1794584 | F | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | 63,980 | ALA1201862 | assay format | PubChem BioAssays | ||
| 14. | ALA2354221 | F | PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT. (Class of assay: confirmatory) | 172,532 | ALA1201862 | assay format | PubChem BioAssays | ||
| 15. | ALA2354254 | F | PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory) | 153,867 | ALA1201862 | assay format | PubChem BioAssays | ||
| 16. | ALA2354282 | F | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | 9,957 | ALA1201862 | assay format | PubChem BioAssays | ||
| 17. | ALA3215017 | F | PubChem BioAssay. qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS. (Class of assay: confirmatory) | 26,949 | ALA1201862 | assay format | PubChem BioAssays | ||
| 18. | ALA3215270 | F | PubChem BioAssay. qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS. (Class of assay: confirmatory) | 22,758 | ALA1201862 | assay format | PubChem BioAssays | ||
| 19. | ALA4001885 | B | Inhibition of protease activity of recombinant full length Clostridium botulinum Hall BoNT/A light chain using SNAP-25 peptide (187 to 203 residues) as substrate after 5 mins by HPLC analysis | Clostridium botulinum A str. Hall | 46 | ALA4000225 | single protein format | Scientific Literature | |
| 20. | ALA4001886 | B | Inhibition of Clostridium botulinum Hall BoNT/A light chain-induced paralysis in CD1 mouse phrenic nerve diaphragm assessed as compound concentration required to cause delay in time to 50% loss of twitch tension evoked by nerve stimulation preincubated with BoNT/A light chain for 15 to 20 mins followed by addition to diaphragm | Clostridium botulinum A str. Hall | 29 | ALA4000225 | single protein format | Scientific Literature |
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