| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1694357 | F | Activation of Nrf2/ARE in rat PC12 cells assessed as upregulation of HO-1 protein expression at 10 uM after 12 hrs by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA1694358 | F | Induction of nuclear translocation of Nrf2 in rat PC12 cells at 10 uM after 6 hrs by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA1694359 | F | Activation of Nrf2/ARE in rat PC12 cells assessed as upregulation of HO-1 protein expression at 10 uM after 6 hrs by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA1694360 | F | Activation of Nrf2/ARE in rat PC12 cells assessed as upregulation of HO-1 mRNA expression at 10 uM after 6 hrs by RT-PCR | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA1694361 | F | Activation of Nrf2/ARE in rat PC12 cells assessed as induction of GCSc protein expression at 10 uM by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA1694362 | F | Activation of Nrf2/ARE in rat PC12 cells assessed as induction of NQO-1 protein expression by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA1694363 | F | Induction of NRF2/ARE enhancer activity rat PC12 cells transfected with ARE-firefly luciferase reporter gene at 10 uM after 24 hrs by luciferase assay | Rattus norvegicus | 8 | cell-based format | Scientific Literature | ||
| 8. | ALA1694364 | B | Phosphorylation of JNK in rat PC12 cells at 10 uM up to 120 mins by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA1694365 | B | Phosphorylation of p38 kinase in rat PC12 cells at 10 uM up to 120 mins by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA1694366 | B | Phosphorylation of ERK1 in rat PC12 cells at 10 uM after 30 mins by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA1694367 | B | Phosphorylation of ERK2 in rat PC12 cells at 10 uM after 30 mins by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA1694368 | F | Activation of Nrf2/ARE in rat PC12 cells assessed as HO-1 protein induction at 10 uM after 5 hrs pretreated with p38 inhibitor SB203580 for 1 hr before compound addition by Western blot analysis | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA1694369 | F | Activation of Nrf2/ARE in rat PC12 cells assessed as HO-1 protein induction at 10 uM after 5 hrs pretreated with MEK1 inhibitor PD98059 for 1 hr before compound addition by Western blot analysis | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 14. | ALA1694370 | F | Activation of Nrf2/ARE in rat PC12 cells assessed as HO-1 protein induction at 10 uM after 5 hrs pretreated with MEK2 inhibitor U0126 for 1 hr before compound addition by Western blot analysis | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA1694371 | F | Activation of Nrf2/ARE in rat PC12 cells assessed as HO-1 protein induction at 10 uM after 5 hrs pretreated with JNK inhibitor SP600125 for 1 hr before compound addition by Western blot analysis | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA1694372 | F | Increase in intracellular ROS production in rat PC12 cells at 10 uM up to 1 hr by CM-H2-DCFDA staining-based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA1694373 | F | Increase in intracellular ROS production in rat PC12 cells at 10 uM after 0.5 hr by CM-H2-DCFDA staining-based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA1694374 | F | Increase in intracellular ROS production in rat PC12 cells assessed as induction of p38 phosphorylation at 10 uM after 1 hr by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA1694375 | F | Increase in intracellular ROS production in rat PC12 cells assessed as NRF2-mediated HO-1 induction at 10 uM after 24 hrs pretreated with N-acetylcysteine for 1 hr before compound addition by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA1694376 | F | Increase in intracellular ROS production in rat PC12 cells assessed as induction of p38 phosphorylation at 10 uM after 1 hr pretreated with N-acetylcysteine for 1 hr before compound addition by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature |
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