# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1794401 | Functional | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | 91,504 | ALA1201862 | assay format | PubChem BioAssays | ||
2. | ALA1738588 | Functional | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | Homo sapiens | 94,040 | ALA1201862 | assay format | PubChem BioAssays | |
3. | ALA1737902 | Functional | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485345, AID485355] | 75,513 | ALA1201862 | assay format | PubChem BioAssays | ||
4. | ALA2114816 | Functional | PubChem BioAssay. Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | Mycobacterium tuberculosis H37Rv | 369 | ALA1201862 | biochemical format | PubChem BioAssays | |
5. | ALA2354254 | Functional | PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory) | 153,867 | ALA1201862 | assay format | PubChem BioAssays | ||
6. | ALA3214953 | Functional | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | 20,285 | ALA1201862 | assay format | PubChem BioAssays | ||
7. | ALA4684494 | Binding | Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed as reduction in H3K36 methylation at 100 uM measured upto 9 days by Western blot analysis | Mus musculus | 1 | ALA4680176 | tissue-based format | Scientific Literature | |
8. | ALA4684495 | Binding | Binding affinity to recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in melting temperature at 100 uM incubated for 1 min by 1,8-ANS probe based thermal shift assay | Homo sapiens | 7 | ALA4680176 | assay format | Scientific Literature | |
9. | ALA4684497 | Binding | Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed as reduction in H3K79 methylation at 100 uM measured upto 9 days by Western blot analysis | Mus musculus | 1 | ALA4680176 | tissue-based format | Scientific Literature | |
10. | ALA4684498 | Binding | Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed as reduction in H3K27 methylation at 100 uM measured upto 9 days by Western blot analysis | Mus musculus | 1 | ALA4680176 | tissue-based format | Scientific Literature | |
11. | ALA4684499 | Binding | Inhibition of recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) using nucleosome as substrate incubated for 1 hr in presence of [3H]-SAM by liquid scintillation counting method | Homo sapiens | 11 | ALA4680176 | assay format | Scientific Literature |