# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA652632 | Binding | Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacae | Enterobacter cloacae | 22 | ALA1132742 | single protein format | Scientific Literature | |
2. | ALA650684 | Binding | Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli | Enterobacter cloacae | 22 | ALA1132742 | single protein format | Scientific Literature | |
3. | ALA3376289 | Binding | Inhibition of His-tagged Escherichia coli DXR at 20 uM pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in absence of 0.01% Triton X100 | Escherichia coli | 1 | ALA3352327 | single protein format | Scientific Literature | |
4. | ALA3376291 | Binding | Inhibition of His-tagged Escherichia coli DXR at 20 uM pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in presence of 0.01% Triton X100 | Escherichia coli | 6 | ALA3352327 | single protein format | Scientific Literature | |
5. | ALA3379868 | Binding | Inhibition of Thermus flavus MDH at 50 uM pre-incubated for 4 mins before reaction initiation in presence of OAA and NAPH in absence of 0.01% Triton X100 by UV-Vis spectrophotometry | Thermus thermophilus | 1 | ALA3352327 | single protein format | Scientific Literature | |
6. | ALA3379871 | Binding | Inhibition of Thermus flavus MDH pre-incubated for 4 mins before reaction initiation in presence of OAA and NAPH in presence of 0.01% Triton X100 by UV-Vis spectrophotometry | Thermus thermophilus | 2 | ALA3352327 | single protein format | Scientific Literature | |
7. | ALA954412 | Binding | Inhibition of Trypanosoma brucei DPMS expressed in Escherichia coli assessed as residual enzyme activity at 1 mM relative to untreated control | Trypanosoma brucei | 10 | ALA1153287 | assay format | Scientific Literature | |
8. | ALA954413 | Functional | Antitrypanosomal activity against Trypanosoma brucei 427 | Trypanosoma brucei | 10 | ALA1153287 | organism-based format | Scientific Literature | |
9. | ALA954414 | ADME | Cytotoxicity against human HeLa cells by alamar blue assay | Homo sapiens | 6 | ALA1153287 | cell-based format | Scientific Literature | |
10. | ALA4121745 | Binding | Inhibition of recombinant bacterial NDM1 expressed in Escherichia coli BL21 (DE3) cells using FC5 as fluorogenic reporter substrate preincubated at 10 to 300 mins followed by substrate addition | Bacteria | 59 | ALA4118127 | cell-based format | Scientific Literature | |
11. | ALA4121746 | Binding | Inhibition of recombinant full-length bacterial His6-tagged SPM1 (29 to 276 residues) expressed in Escherichia coli BL21 (DE3) cells using FC4-FC5 as substrate by fluorescence-based assay | Bacteria | 59 | ALA4118127 | cell-based format | Scientific Literature | |
12. | ALA4121747 | Binding | Inhibition of recombinant bacterial IMP1 expressed in Escherichia coli BL21 (DE3) cells using FC4-FC5 as substrate by fluorescence-based assay | Bacteria | 59 | ALA4118127 | cell-based format | Scientific Literature | |
13. | ALA4121748 | Binding | Inhibition of recombinant Bacillus cereus BC2 expressed in Escherichia coli BL21 (DE3) cells using FC4-FC5 as substrate by fluorescence-based assay | Bacillus cereus | 59 | ALA4118127 | cell-based format | Scientific Literature | |
14. | ALA4121749 | Binding | Inhibition of recombinant full-length bacterial His6-tagged VIM2 (27 to 266 residues) expressed in Escherichia coli BL21 (DE3) cells using FC4-FC5 as substrate by fluorescence-based assay | Bacteria | 59 | ALA4118127 | cell-based format | Scientific Literature | |
15. | ALA4121766 | Binding | Inhibition of recombinant N-terminal His-tagged Escherichia coli TEM1 (24 to 286 residues) expressed in Escherichia coli BL21(DE3) at 200 uM using FC5 as substrate | Escherichia coli | 57 | ALA4118127 | assay format | Scientific Literature | |
16. | ALA4121767 | Binding | Inhibition of recombinant Escherichia coli EO516 N-terminal His6-tagged CTX-M using FC5 as substrate at 200 uM preincubated at 10 to 300 mins followed by substrate addition | Escherichia coli | 57 | ALA4118127 | single protein format | Scientific Literature | |
17. | ALA4121768 | Binding | Inhibition of recombinant Escherichia coli AmpC at 200 uM using FC5 as substrate preincubated at 10 to 300 mins followed by substrate addition | Escherichia coli | 57 | ALA4118127 | single protein format | Scientific Literature | |
18. | ALA4121769 | Binding | Inhibition of recombinant Pseudomonas aeruginosa OXA-10 at 200 uM using FC5 as substrate | Pseudomonas aeruginosa | 57 | ALA4118127 | single protein format | Scientific Literature | |
19. | ALA4256439 | Binding | Inhibition of bacterial ImiS expressed in Escherichia coli BL21(DE3) at 50 uM using imipenem as substrate by spectrometric method relative to control | Bacteria | 16 | ALA4251739 | assay format | Scientific Literature | |
20. | ALA4256442 | Binding | Inhibition of bacterial L1 expressed in Escherichia coli BL21(DE3) using cefazolin as substrate by spectrometric method | Bacteria | 27 | ALA4251739 | assay format | Scientific Literature |