| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4004648 | B | Induction of R-state stabilization of Hb betaGlu6Val mutant in sickle disease patient purified HbS/HbA mixture assessed as change from baseline of partial pressure of O2 at which HbS is 50% saturated with O2 at 30 uM preincubated for 45 mins followed by oxygenation for 10 mins and subsequent deoxygenation by hemoximetry relative to control | Homo sapiens | 42 | assay format | Scientific Literature | ||
| 2. | ALA4004674 | B | Induction of R-state stabilization of Hb betaGlu6Val mutant in sickle disease patient purified HbS/HbA mixture assessed as change from baseline of partial pressure of O2 at which HbS is 50% saturated with O2 at 100 uM preincubated for 45 mins followed by 20 mins oxygenation/deoxygenation cycle by hemoximetry relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 3. | ALA4223611 | F | Antisickling activity in human homozygous sickle red blood cells at 2 mM incubated for 2 hrs under hypoxic condition relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA4223612 | F | Antisickling activity in human homozygous sickle red blood cells at 1 mM incubated for 2 hrs under hypoxic condition relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA4223613 | B | Inhibition of sickle hemoglobin polymerization in human homozygous sickle red blood cells assessed as formation of high oxygen affinity schiff-base adducts at 0.5 mM incubated under air for 1 hr followed by 2 hrs incubation under hypoxic condition by HPLC method relative to control | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 6. | ALA4223614 | B | Induction of R-state stabilization of Hb in human homozygous sickle red blood cells assessed as change in oxygen pressure at which hemolysates are 50% saturated with oxygen at 2 mM incubated under air for 1 hr followed by 2 hrs incubation under hypoxic condition by oxygen equilibrium curve analysis relative to control | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 7. | ALA4223615 | B | Inhibition of sickle hemoglobin polymerization in human homozygous sickle red blood cells assessed as formation of high oxygen affinity schiff-base adducts at 1 mM incubated under air for 1 hr followed by 2 hrs incubation under hypoxic condition by HPLC method relative to control | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 8. | ALA4223616 | B | Inhibition of sickle hemoglobin polymerization in human homozygous sickle red blood cells assessed as formation of high oxygen affinity schiff-base adducts at 2 mM incubated under air for 1 hr followed by 2 hrs incubation under hypoxic condition by HPLC method relative to control | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 9. | ALA4223617 | B | Induction of R-state stabilization of Hb in human homozygous sickle red blood cells assessed as change in oxygen pressure at which hemolysates are 50% saturated with oxygen at 0.5 mM incubated under air for 1 hr followed by 2 hrs incubation under hypoxic condition by oxygen equilibrium curve analysis relative to control | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 10. | ALA4223618 | B | Induction of R-state stabilization of Hb in human homozygous sickle red blood cells assessed as change in oxygen pressure at which hemolysates are 50% saturated with oxygen at 1 mM incubated under air for 1 hr followed by 2 hrs incubation under hypoxic condition by oxygen equilibrium curve analysis relative to control | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 11. | ALA4223619 | F | Antisickling activity in human homozygous sickle red blood cells at 0.5 mM incubated for 2 hrs under hypoxic condition relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA4223620 | B | Inhibition of sickle hemoglobin polymerization in human cell free hemoglobin matrix assessed as formation of high oxygen affinity schiff-base adducts incubated for 60 to 90 mins by HPLC method relative to control | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
| 13. | ALA4223622 | B | Inhibition of sickle hemoglobin polymerization in human whole blood assessed as formation of high oxygen affinity schiff-base adducts by HPLC method | Homo sapiens | 5 | protein complex format | Scientific Literature | ||
| 14. | ALA4223623 | B | Inhibition of sickle hemoglobin polymerization in human whole blood assessed as formation of high oxygen affinity schiff-base adducts at 2 mM after 2 hrs by HPLC method relative to control | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 15. | ALA4223624 | B | Inhibition of sickle hemoglobin polymerization in human whole blood assessed as formation of high oxygen affinity schiff-base adducts at 2 mM measured up to 24 hrs by HPLC method relative to control | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
| 16. | ALA4223626 | B | Inhibition of sickle hemoglobin polymerization in human whole blood assessed as formation of high oxygen affinity schiff-base adducts at 2 mM measured at 2 hrs by HPLC method relative to control | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 17. | ALA4223627 | B | Inhibition of sickle hemoglobin polymerization in human whole blood assessed as formation of high oxygen affinity schiff-base adducts at 2 mM measured after 24 hrs by HPLC method relative to control | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
| 18. | ALA4223628 | F | Antisickling activity in human homozygous sickle red blood cells incubated for 2 hrs under hypoxic condition | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 19. | ALA4223629 | B | Inhibition of sickle hemoglobin polymerization in human homozygous sickle red blood cells assessed as formation of high oxygen affinity schiff-base adducts incubated under air for 1 hr followed by 2 hrs incubation under hypoxic condition by HPLC method | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 20. | ALA4223630 | B | Induction of R-state stabilization of Hb in human homozygous sickle red blood cells assessed as change in oxygen pressure at which hemolysates are 50% saturated with oxygen incubated under air for 1 hr followed by 2 hrs incubation under hypoxic condition by oxygen equilibrium curve analysis | Homo sapiens | 5 | assay format | Scientific Literature |
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