# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1960606 | A | Oral bioavailability in Sprague-Dawley rat at 21.2 mg/kg | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
2. | ALA1960610 | A | Ratio of drug level in blood to plasma in Sprague-Dawley rat at 2 to 21.2 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
3. | ALA1960612 | A | Plasma protein binding in Sprague-Dawley rat at 2 to 21.2 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
4. | ALA1960614 | B | Selectivity ratio of IC50 for Plasmodium falciparum C-terminal hexa-His tagged DHODH to IC50 for Plasmodium berghei C-terminal hexa-His tagged DHODH | 2 | assay format | Scientific Literature | |||
5. | ALA1960615 | B | Inhibition of Plasmodium vivax C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay | Plasmodium vivax | 2 | assay format | Scientific Literature | ||
6. | ALA1960616 | F | Antimalarial activity against Plasmodium falciparum 3D7 0087/N9 infected in human RBC engrafted NOD-SCID IL-2Rgamma-null mouse assessed as reduction in parasitemia administered orally 3 days post infection qd for 4 days measured 24 hrs after final dose by FACS analysis | Plasmodium falciparum | 5 | organism-based format | Scientific Literature | ||
7. | ALA1960618 | A | AUC (0 to 10 hrs) in human RBC engrafted NOD-SCID IL-2Rgamma-null mouse at 5.7 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
8. | ALA1960621 | A | AUC (0 to 10 hrs) in human RBC engrafted NOD-SCID IL-2Rgamma-null mouse infected with Plasmodium falciparum 3D7 0087/N9 at 5.7 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
9. | ALA1960624 | A | Cmax in human RBC engrafted NOD-SCID IL-2Rgamma-null mouse at 5.7 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
10. | ALA1960627 | A | Cmax in human RBC engrafted NOD-SCID IL-2Rgamma-null mouse infected with Plasmodium falciparum 3D7 0087/N9 at 5.7 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
11. | ALA1960630 | A | Tmax in human RBC engrafted NOD-SCID IL-2Rgamma-null mouse at 5.7 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
12. | ALA1960725 | A | Tmax in human RBC engrafted NOD-SCID IL-2Rgamma-null mouse infected with Plasmodium falciparum 3D7 0087/N9 at 5.7 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
13. | ALA1961096 | B | Inhibition of Plasmodium falciparum C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay | Plasmodium falciparum | 83 | assay format | Scientific Literature | ||
14. | ALA1961097 | B | Inhibition of Plasmodium berghei C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay | Plasmodium berghei | 83 | assay format | Scientific Literature | ||
15. | ALA1961098 | B | Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay | Homo sapiens | 83 | assay format | Scientific Literature | ||
16. | ALA1961099 | F | Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay in presence of human serum | Plasmodium falciparum | 83 | organism-based format | Scientific Literature | ||
17. | ALA1961100 | F | Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay in presence of albumax | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
18. | ALA1961102 | P | Lipophilicity, log D of the compound at pH 7.4 | 25 | small-molecule physicochemical format | Scientific Literature | |||
19. | ALA1961103 | P | Aqueous solubility of the compound at pH 6.5 | 25 | small-molecule physicochemical format | Scientific Literature | |||
20. | ALA1960900 | A | Plasma protein binding in human by chromatographic method | Homo sapiens | 25 | cell-free format | Scientific Literature |