| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1764035 | F | Inhibition of 11beta-HSD1 in ICR mouse assessed as inhibition of conversion of [3H]-cortisone to [3H]-cortisol at 10 mg/kg, po administered 16 hrs before [3H]-cortisone challenge | Mus musculus | 28 | organism-based format | Scientific Literature | ||
| 2. | ALA1764080 | F | Inhibition of 11beta-HSD1 in ICR mouse assessed as inhibition of conversion of [3H]-cortisone to [3H]-cortisol at 10 mg/kg, po administered 4 hrs before [3H]-cortisone challenge | Mus musculus | 32 | organism-based format | Scientific Literature | ||
| 3. | ALA1764081 | B | Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assay | Mus musculus | 35 | cell-based format | Scientific Literature | ||
| 4. | ALA1764082 | B | Inhibition of mouse 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assay | Mus musculus | 35 | cell-based format | Scientific Literature | ||
| 5. | ALA1764083 | B | Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assay | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 6. | ALA1764084 | B | Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assay | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 7. | ALA1764085 | A | Normalized AUC in C57 mouse at 10 mg/kg, po | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 8. | ALA1764086 | A | Clearance in C57 mouse at 2 mg/kg, iv | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 9. | ALA1764087 | A | Bioavailability in C57 mouse at 2 mg/kg, iv and 10 mg/kg, po | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 10. | ALA1764088 | A | Volume of distribution in C57 mouse at 2 mg/kg, iv and 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA1764089 | A | Half life in C57 mouse at 2 mg/kg, iv and 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA1764090 | A | Normalized Cmax in C57 mouse at 2 mg/kg, iv and 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA1764091 | A | Tmax in C57 mouse at 2 mg/kg, iv and 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA1764092 | A | Normalized AUC in Sprague-Dawley rat at 4 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA1764093 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv and 4 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA1764094 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv and 4 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA1764095 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv and 4 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA1764096 | A | Normalized Cmax in Sprague-Dawley rat at 1 mg/kg, iv and 4 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA1764097 | A | Tmax in Sprague-Dawley rat at 1 mg/kg, iv and 4 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA1764098 | A | Bioavailability in Sprague-Dawley rat 1 mg/kg, iv and 4 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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