# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1764035 | F | Inhibition of 11beta-HSD1 in ICR mouse assessed as inhibition of conversion of [3H]-cortisone to [3H]-cortisol at 10 mg/kg, po administered 16 hrs before [3H]-cortisone challenge | Mus musculus | 28 | organism-based format | Scientific Literature | ||
2. | ALA1764080 | F | Inhibition of 11beta-HSD1 in ICR mouse assessed as inhibition of conversion of [3H]-cortisone to [3H]-cortisol at 10 mg/kg, po administered 4 hrs before [3H]-cortisone challenge | Mus musculus | 32 | organism-based format | Scientific Literature | ||
3. | ALA1764081 | B | Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assay | Mus musculus | 35 | cell-based format | Scientific Literature | ||
4. | ALA1764082 | B | Inhibition of mouse 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assay | Mus musculus | 35 | cell-based format | Scientific Literature | ||
5. | ALA1764083 | B | Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assay | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
6. | ALA1764084 | B | Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assay | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
7. | ALA2396026 | A | P-glycoprotein (unknown origin)-mediated permeability assessed as efflux ratio from basolateral to apical side to apical to basolateral side at 24 hrs | Not specified | 4 | assay format | Scientific Literature | ||
8. | ALA2396027 | F | Antihypertensive activity in spontaneously hypertensive rat model assessed as reduction in heart rate at 10 mg/kg for 7 days | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
9. | ALA2396029 | A | P-glycoprotein (unknown origin)-mediated permeability assessed as efflux ratio from basolateral to apical side to apical to basolateral side at 4 hrs | Not specified | 4 | assay format | Scientific Literature | ||
10. | ALA2396030 | A | Ratio of drug level in brain to plasma of spontaneously hypertensive rat at 10 mg/kg | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
11. | ALA2396032 | A | Drug level in spontaneously hypertensive rat CSF at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
12. | ALA2396033 | A | Total drug level in spontaneously hypertensive rat brain at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
13. | ALA2396034 | A | Free drug level in spontaneously hypertensive rat brain at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
14. | ALA2396035 | A | Drug level in spontaneously hypertensive rat CSF at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
15. | ALA2396036 | A | Free plasma concentration in spontaneously hypertensive rat at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
16. | ALA2396037 | A | Total drug level in spontaneously hypertensive rat brain at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
17. | ALA2396038 | A | Free drug level in spontaneously hypertensive rat brain at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
18. | ALA2396039 | A | Free plasma concentration in spontaneously hypertensive rat at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
19. | ALA2396040 | A | Plasma concentration in spontaneously hypertensive rat model at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
20. | ALA2396041 | A | Plasma concentration in spontaneously hypertensive rat model at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature |