The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
The page will load shortly, Thanks for your patience!
# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA1771961 B Displacement of [125]sauvagin from rat recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells Rattus norvegicus 1 ALA1770105 cell-based format Scientific Literature 2. ALA1771962 B Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells Homo sapiens 13 ALA1770105 cell-based format Scientific Literature 3. ALA1771963 F Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay Homo sapiens 3 ALA1770105 cell-based format Scientific Literature 4. ALA1771964 A Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv and 3 mg/kg, po Rattus norvegicus 3 ALA1770105 organism-based format Scientific Literature 5. ALA1771965 A Fraction unbound in Sprague-Dawley rat plasma at 1 mg/kg, iv and 3 mg/kg, po Rattus norvegicus 3 ALA1770105 organism-based format Scientific Literature 6. ALA1771966 A Unbound plasma clearance in Sprague-Dawley rat 1 mg/kg, iv and 3 mg/kg, po Rattus norvegicus 3 ALA1770105 organism-based format Scientific Literature 7. ALA1771967 F Antihypertensive activity in Sprague-Dawley rat assessed as inhibition of NPY-induced increase in arterial pressure at 3 mg/kg, iv Rattus norvegicus 3 ALA1770105 organism-based format Scientific Literature 8. ALA1771968 A Half life in Sprague-Dawley rat at 1 mg/kg, iv and 3 mg/kg, po Rattus norvegicus 1 ALA1770105 organism-based format Scientific Literature 9. ALA1771969 A Oral bioavailability in Sprague-Dawley rat at 3 mg/kg Rattus norvegicus 1 ALA1770105 organism-based format Scientific Literature 10. ALA1771970 A Ratio of fraction unbound drug level in brain to plasma in Sprague-Dawley rat Rattus norvegicus 1 ALA1770105 cell-free format Scientific Literature 11. ALA1771971 A Ratio of fraction unbound drug level in brain to plasma in FVB mouse Mus musculus 1 ALA1770105 cell-free format Scientific Literature 12. ALA1771972 A Ratio of fraction unbound drug level in brain to plasma in Mdr1a/1b knockout mouse to FVB mouse at 5 mg.kg, sc after 0.5 hrs Mus musculus 6 ALA1770105 organism-based format Scientific Literature 13. ALA1771973 F Antiobesity activity in Sprague-Dawley rat assessed as reduction of NPY-induced food intake at 120 ug, icv after 4 hrs Rattus norvegicus 1 ALA1770105 organism-based format Scientific Literature 14. ALA1771974 F Antiobesity activity in overnight fasted Sprague-Dawley rat assessed as decrease in food intake at 40 mg/kg, po followed by food re-feeding after 2 hrs post compound dose measured upto 2 hrs post re-feeding relative to control Rattus norvegicus 1 ALA1770105 organism-based format Scientific Literature 15. ALA1771975 F Antiobesity activity in overnight fasted Sprague-Dawley rat assessed as decrease in food intake at 40 mg/kg, po followed by food re-feeding after 4 hrs post compound dose measured up to 2 to 4 hrs post re-feeding Rattus norvegicus 1 ALA1770105 organism-based format Scientific Literature 16. ALA1771976 T Neurotoxicity in Sprague-Dawley rat assessed as change in locomotor activity at 40 mg/kg, po Rattus norvegicus 1 ALA1770105 organism-based format Scientific Literature 17. ALA1771977 F Antiobesity activity in Wistar rat assessed as decrease in nocturnal food intake at 40 mg/kg, po measured every 10 mins for 18 hrs post-dose Rattus norvegicus 1 ALA1770105 organism-based format Scientific Literature 18. ALA1772028 T Neurotoxicity in Wistar rat assessed as change in locomotor activity at 40 mg/kg, po Rattus norvegicus 1 ALA1770105 organism-based format Scientific Literature 19. ALA1772029 A Unbound plasma concentration in Sprague-Dawley rat at 40 mg/kg, po after 2 hrs Rattus norvegicus 1 ALA1770105 organism-based format Scientific Literature 20. ALA1772030 B Binding affinity to human NPY Y2 receptor Homo sapiens 1 ALA1770105 single protein format Scientific Literature