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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA1771961 B Displacement of [125]sauvagin from rat recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells Rattus norvegicus 1 cell-based format Scientific Literature 2. ALA1771962 B Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells Homo sapiens 13 cell-based format Scientific Literature 3. ALA1771963 F Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay Homo sapiens 3 cell-based format Scientific Literature 4. ALA1771964 A Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv and 3 mg/kg, po Rattus norvegicus 3 organism-based format Scientific Literature 5. ALA1771965 A Fraction unbound in Sprague-Dawley rat plasma at 1 mg/kg, iv and 3 mg/kg, po Rattus norvegicus 3 organism-based format Scientific Literature 6. ALA1771966 A Unbound plasma clearance in Sprague-Dawley rat 1 mg/kg, iv and 3 mg/kg, po Rattus norvegicus 3 organism-based format Scientific Literature 7. ALA1771967 F Antihypertensive activity in Sprague-Dawley rat assessed as inhibition of NPY-induced increase in arterial pressure at 3 mg/kg, iv Rattus norvegicus 3 organism-based format Scientific Literature 8. ALA1771968 A Half life in Sprague-Dawley rat at 1 mg/kg, iv and 3 mg/kg, po Rattus norvegicus 1 organism-based format Scientific Literature 9. ALA1771969 A Oral bioavailability in Sprague-Dawley rat at 3 mg/kg Rattus norvegicus 1 organism-based format Scientific Literature 10. ALA1771970 A Ratio of fraction unbound drug level in brain to plasma in Sprague-Dawley rat Rattus norvegicus 1 cell-free format Scientific Literature 11. ALA1771971 A Ratio of fraction unbound drug level in brain to plasma in FVB mouse Mus musculus 1 cell-free format Scientific Literature 12. ALA1771972 A Ratio of fraction unbound drug level in brain to plasma in Mdr1a/1b knockout mouse to FVB mouse at 5 mg.kg, sc after 0.5 hrs Mus musculus 6 organism-based format Scientific Literature 13. ALA1771973 F Antiobesity activity in Sprague-Dawley rat assessed as reduction of NPY-induced food intake at 120 ug, icv after 4 hrs Rattus norvegicus 1 organism-based format Scientific Literature 14. ALA1771974 F Antiobesity activity in overnight fasted Sprague-Dawley rat assessed as decrease in food intake at 40 mg/kg, po followed by food re-feeding after 2 hrs post compound dose measured upto 2 hrs post re-feeding relative to control Rattus norvegicus 1 organism-based format Scientific Literature 15. ALA1771975 F Antiobesity activity in overnight fasted Sprague-Dawley rat assessed as decrease in food intake at 40 mg/kg, po followed by food re-feeding after 4 hrs post compound dose measured up to 2 to 4 hrs post re-feeding Rattus norvegicus 1 organism-based format Scientific Literature 16. ALA1771976 T Neurotoxicity in Sprague-Dawley rat assessed as change in locomotor activity at 40 mg/kg, po Rattus norvegicus 1 organism-based format Scientific Literature 17. ALA1771977 F Antiobesity activity in Wistar rat assessed as decrease in nocturnal food intake at 40 mg/kg, po measured every 10 mins for 18 hrs post-dose Rattus norvegicus 1 organism-based format Scientific Literature 18. ALA1772028 T Neurotoxicity in Wistar rat assessed as change in locomotor activity at 40 mg/kg, po Rattus norvegicus 1 organism-based format Scientific Literature 19. ALA1772029 A Unbound plasma concentration in Sprague-Dawley rat at 40 mg/kg, po after 2 hrs Rattus norvegicus 1 organism-based format Scientific Literature 20. ALA1772030 B Binding affinity to human NPY Y2 receptor Homo sapiens 1 single protein format Scientific Literature