| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1776260 | B | Inhibition of EthR in Mycobacterium tuberculosis H37Rv expressing GFP infected in mouse RAW264.7 cells assessed as concentration required to ethionamide-induced 50% inhibition of bacterial growth after 5 days by microscopic analysis | Mycobacterium tuberculosis H37Rv | 58 | cell-based format | Scientific Literature | ||
| 2. | ALA1776262 | B | Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assay | Mycobacterium tuberculosis | 8 | single protein format | Scientific Literature | ||
| 3. | ALA1776263 | A | Cytotoxicity against mouse RAW264.7 cells at > 30 uM | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA1776264 | P | Solubility of the compound at pH 7.4 after 24 hrs | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA1776265 | A | Half life in CD1 mouse liver microsomes by LC-MS-MS analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 6. | ALA1776266 | A | Intrinsic clearance in CD1 mouse liver microsomes by LC-MS-MS analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 7. | ALA1947970 | A | Half life in CD-1 mouse liver microsomes at 1 uM by LC-MS/MS analysis | Mus musculus | 6 | microsome format | Scientific Literature | ||
| 8. | ALA1947971 | A | Intrinsic clearance in CD-1 mouse liver microsomes at 1 uM by LC-MS/MS analysis | Mus musculus | 6 | microsome format | Scientific Literature | ||
| 9. | ALA1947972 | P | Solubility of the compound in PBS buffer at pH 7.4 after 24 hrs by LC-MS analysis | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 10. | ALA1947973 | B | Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assay | 6 | single protein format | Scientific Literature | |||
| 11. | ALA1947974 | B | Inhibition of Mycobacterium tuberculosis H37Rv EthR in Mycobacterium tuberculosis H37Rv expressing GFP infected mouse in RAW264.7 cells assessed as potentiation of ethionamide-induced antitubercular activity after 5 days by SYTO60-based fluorescence microscopy | Mycobacterium tuberculosis H37Rv | 41 | cell-based format | Scientific Literature | ||
| 12. | ALA1947975 | A | AUC (0 to infinity) in Swiss mouse at 20 mg/kg, po administered with 100% DMSO by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!