| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1777341 | B | Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assay | Homo sapiens | 27 | assay format | Scientific Literature | ||
| 2. | ALA1777342 | B | Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 at 10 uM by HPLC assay relative to control | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 3. | ALA1777343 | B | Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production at 10 uM after 10 mins by RP-HPLC assay relative to control | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 4. | ALA1777433 | B | Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assay | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 5. | ALA1777434 | B | Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production at 10 uM after 10 mins by RP-HPLC assay relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 6. | ALA1777435 | B | Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 7. | ALA3384862 | B | Competitive inhibition of N-terminal His-tagged Lyp (unknown origin) catalytic domain (1 to 294 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in pNPP hydrolysis by Lineweaver-Burk plot | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 8. | ALA3384863 | B | Reversible inhibition of N-terminal His-tagged Lyp (unknown origin) catalytic domain (1 to 294 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in pNPP hydrolysis by Lineweaver-Burk plot | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 9. | ALA3384865 | B | Inhibition of PTPN18 (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 10. | ALA3384866 | B | Inhibition of STEP (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 11. | ALA3384867 | B | Inhibition of MEG2 (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA3386717 | B | Inhibition of PTP1B (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA3386718 | B | Inhibition of VHR (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 14. | ALA3386719 | B | Inhibition of SSH2 (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 15. | ALA3386720 | B | Inhibition of PPM1A (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 16. | ALA3386721 | B | Inhibition of PPM1G (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 17. | ALA3386722 | B | Selectivity index, ratio of IC50 for PTP1B (unknown origin) to IC50 for N-terminal His-tagged Lyp (unknown origin) catalytic domain (1 to 294 residues) | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 18. | ALA3386723 | B | Inhibition of Lyp in antiCD3-antibody-stimulated human JTAg cells assessed as increase in TCR-induced LCK Y394 phosphorylation at 20 uM by immunoblotting method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA3386724 | B | Inhibition of Lyp in antiCD3-antibody-stimulated human JTAg cells assessed as increase in TCR-induced ERK phosphorylation at 20 uM by immunoblotting method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA3795790 | B | Inhibition of KDM5A (unknown origin) using substrate peptide/ascorbate/2-OG/ Fe(2) as substrate preincubated for 15 mins followed by addition of substrate peptide/ ascorbate/2-OG/ Fe(2) measured after 1 hr by AlphaLISA method | Homo sapiens | 13 | single protein format | Scientific Literature |
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