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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA1804265 B Binding affinity to chimpanzee P2Y14 receptor Pan troglodytes 2 assay format Scientific Literature 2. ALA1804288 A Oral bioavailability in mouse at 75 mg/kg bid Mus musculus 1 organism-based format Scientific Literature 3. ALA1804289 A Half life in mouse at 75 mg/kg, po bid Mus musculus 1 organism-based format Scientific Literature 4. ALA1804290 A Clearance in mouse at 75 mg/kg, po bid Mus musculus 1 organism-based format Scientific Literature 5. ALA1804443 B Binding affinity to 4.5 % human serum albumin Homo sapiens 1 single protein format Scientific Literature 6. ALA1804444 B Binding affinity to chimpanzee P2Y14 receptor in presence of 2% human serum albumin Pan troglodytes 2 assay format Scientific Literature 7. ALA1776795 F Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay Mus musculus 21 cell-based format Scientific Literature 8. ALA1776796 F Antagonist activity at chimpanzee P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay Pan troglodytes 21 cell-based format Scientific Literature 9. ALA1776797 B Displacement of [3H]-UDP from chimpanzee P2Y14 receptor expressed in HEK293 cells Pan troglodytes 20 cell-based format Scientific Literature 10. ALA1776799 A Metabolic stability in C57BL/6 mouse Hepatocyte assessed as parent compound remaining at 20 uM after 2 hrs Mus musculus 7 cell-based format Scientific Literature 11. ALA1776800 A Oral bioavailability in C57BL/6 mouse at 50 mg/kg, po administered in 5% Tween-80 Mus musculus 6 organism-based format Scientific Literature 12. ALA1776802 A Intrinsic clearance in C57BL/6 mouse at 2 mg/kg, iv administered in 60% PEG-200 Mus musculus 7 organism-based format Scientific Literature 13. ALA1776803 A Half life in C57BL/6 mouse at 50 mg/kg, po and 2 mg/kg, iv Mus musculus 7 organism-based format Scientific Literature 14. ALA1776859 A Cmax in C57BL/6 mouse at 50 mg/kg, po administered in 5% Tween-80 Mus musculus 6 organism-based format Scientific Literature 15. ALA3721017 F Antagonist activity against chimpanzee GPR105 expressed in stable HEK cells co-expressing chimeric G-protein Gqi5 assessed as inhibition of UDP-glucose-induced Ca2+ signaling response incubated for 20 mins by FLIPR assay Pan troglodytes 40 cell-based format Patent Bioactivity Data 16. ALA4349431 B Inhibition of mouse P2Y14 receptor Mus musculus 2 single protein format Scientific Literature 17. ALA4349433 A Oral bioavailability in C57BL/6 mouse at 50 mg/kg Mus musculus 1 organism-based format Scientific Literature 18. ALA4349434 A Clearance in C57BL/6 mouse at 50 mg/kg, po Mus musculus 1 organism-based format Scientific Literature 19. ALA4349435 A Half life in C57BL/6 mouse at 50 mg/kg, po Mus musculus 1 organism-based format Scientific Literature 20. ALA4349436 A Cmax in C57BL/6 mouse at 50 mg/kg, po Mus musculus 1 organism-based format Scientific Literature