# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1780687 | Binding | Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assay | 46 | ALA1777748 | single protein format | Scientific Literature | ||
2. | ALA1780688 | ADME | Intrinsic clearance in rat hepatocytes assessed per 1 x 10'6 cells | Rattus norvegicus | 38 | ALA1777748 | cell-based format | Scientific Literature | |
3. | ALA1780689 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 38 | ALA1777748 | microsome format | Scientific Literature | |
4. | ALA1780693 | Binding | Intrinsic activity at human CRTh2 receptor in human eosinophils assessed as stimulation of DK-PGD2-induced up-regulation of CD11b expression after 15 mins by flow cytometry relative to DK-PGD2 | Homo sapiens | 30 | ALA1777748 | assay format | Scientific Literature | |
5. | ALA1780695 | Functional | Antagonist activity at human CRTh2 receptor expressed in CHO cells assessed as inhibition of PGD2-induced calcium flux in presence of 1% bovine serum albumin | Homo sapiens | 2 | ALA1777748 | cell-based format | Scientific Literature | |
6. | ALA1780696 | Binding | Selectivity ratio of DP1 receptor to human CRTh2 receptor | 2 | ALA1777748 | assay format | Scientific Literature | ||
7. | ALA1780697 | ADME | Half life in iv dosed rat | Rattus norvegicus | 2 | ALA1777748 | organism-based format | Scientific Literature | |
8. | ALA1780698 | ADME | Oral bioavailability in rat | Rattus norvegicus | 2 | ALA1777748 | organism-based format | Scientific Literature | |
9. | ALA1780699 | Binding | Selectivity ratio of prostanoid TP receptor to human CRTh2 receptor | 1 | ALA1777748 | assay format | Scientific Literature | ||
10. | ALA1780736 | Binding | Selectivity ratio of COX1 to human CRTh2 receptor | 1 | ALA1777748 | assay format | Scientific Literature | ||
11. | ALA1780737 | ADME | Inhibition of CYP1A2 | 1 | ALA1777748 | single protein format | Scientific Literature | ||
12. | ALA1780738 | ADME | Inhibition of CYP3A4 | 1 | ALA1777748 | single protein format | Scientific Literature | ||
13. | ALA1780739 | ADME | Inhibition of CYP2C9 | 1 | ALA1777748 | single protein format | Scientific Literature | ||
14. | ALA1780740 | ADME | Inhibition of CYP2C19 | 1 | ALA1777748 | single protein format | Scientific Literature | ||
15. | ALA1780741 | ADME | Inhibition of CYP2D6 | 1 | ALA1777748 | single protein format | Scientific Literature | ||
16. | ALA1780742 | Binding | Binding affinity to mouse CRTh2 receptor | Mus musculus | 1 | ALA1777748 | single protein format | Scientific Literature | |
17. | ALA1780743 | Binding | Binding affinity to rat CRTh2 receptor | Rattus norvegicus | 1 | ALA1777748 | single protein format | Scientific Literature | |
18. | ALA1780744 | Binding | Binding affinity to guinea pig CRTh2 receptor | Cavia porcellus | 1 | ALA1777748 | single protein format | Scientific Literature | |
19. | ALA1780745 | ADME | Half life in iv dosed dog | Canis lupus familiaris | 1 | ALA1777748 | organism-based format | Scientific Literature | |
20. | ALA1780746 | ADME | Oral bioavailability in dog | Canis lupus familiaris | 1 | ALA1777748 | organism-based format | Scientific Literature |