Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addition measured after 0.75 hrs by beta scintillation counting
Inhibition of cholesterol synthesis in rat hepatocytes assessed as reduction of [14C]-cholesterol level using [14C]-acetic acid preincubated for 4 hrs before addition of [14C]-acetic acid by liquid scintillation counting
Inhibition of cholesterol synthesis in rat L6 cells assessed as reduction of [14C]-cholesterol level using [14C]-acetic acid preincubated for 3 hrs before addition of [14C]-acetic acid by scintillation counting
Inhibition of cholesterol synthesis in golden syrian hamster assessed as reduction of [14C]-cholesterol level at 10 mg/kg, po followed by 2 hrs after treated with 80 uCi, ip of [14C]-sodium acetate measured after 4 hrs by liquid scintillation counting relative to control
Inhibition of cholesterol synthesis in golden syrian hamster assessed as reduction of [14C]-cholesterol level at 10 mg/kg, po followed by 3 hrs after treated with 80 uCi, ip of [14C]-sodium acetate measured after 5 hrs by liquid scintillation counting relative to control
Hypolipidemic activity in chow fed Hartley guinea pig assessed as reduction of LDL level administered orally for 7 days measured on day 8 after 2 hrs post dose