# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1787625 | B | Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hr | 45 | cell-based format | Scientific Literature | |||
2. | ALA1787626 | P | Solubility of the compound in DMSO by LC/MS/MS method | 43 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA1787627 | A | Intrinsic clearance in human liver microsomes at 1 uM after 25 mins by LC/MS/MS analysis in presence of NADPH | Homo sapiens | 45 | microsome format | Scientific Literature | ||
4. | ALA1787628 | B | Allosteric modulation of human GABAA alpha1beta2gamma2 receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at holding potential of -60mV by two-electrode voltage-clamp electrophysiology assay relative to 1 uM Diazepam | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
5. | ALA1787779 | B | Allosteric modulation of human GABAA alpha2beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at holding potential of -60mV by two-electrode voltage-clamp electrophysiology assay relative to 1 uM Diazepam | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
6. | ALA1787780 | B | Allosteric modulation of human GABAA alpha3beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at holding potential of -60mV by two-electrode voltage-clamp electrophysiology assay relative to 1 uM Diazepam | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
7. | ALA3301363 | P | ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 | 4,197 | small-molecule physicochemical format | AstraZeneca Deposited Data |