| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1787625 | B | Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hr | 45 | cell-based format | Scientific Literature | |||
| 2. | ALA1787626 | P | Solubility of the compound in DMSO by LC/MS/MS method | 43 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA1787627 | A | Intrinsic clearance in human liver microsomes at 1 uM after 25 mins by LC/MS/MS analysis in presence of NADPH | Homo sapiens | 45 | microsome format | Scientific Literature | ||
| 4. | ALA1787628 | B | Allosteric modulation of human GABAA alpha1beta2gamma2 receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at holding potential of -60mV by two-electrode voltage-clamp electrophysiology assay relative to 1 uM Diazepam | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 5. | ALA1787779 | B | Allosteric modulation of human GABAA alpha2beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at holding potential of -60mV by two-electrode voltage-clamp electrophysiology assay relative to 1 uM Diazepam | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
| 6. | ALA1787780 | B | Allosteric modulation of human GABAA alpha3beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at holding potential of -60mV by two-electrode voltage-clamp electrophysiology assay relative to 1 uM Diazepam | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 7. | ALA3301363 | P | ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 | 4,197 | small-molecule physicochemical format | AstraZeneca Deposited Data | |||
| 8. | ALA3301372 | A | ASTRAZENECA: Intrinsic clearance measured in human hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736. | Homo sapiens | 408 | cell-based format | AstraZeneca Deposited Data |
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