# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1785143 | F | Antagonist activity at histamine H3 receptor in rat cortical hemispheres assessed as inhibition of forskolin stimulated cAMP accumulation after 6 hrs | Rattus norvegicus | 2 | ALA1782038 | assay format | Scientific Literature | |
2. | ALA1785144 | B | Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells | Homo sapiens | 39 | ALA1782038 | cell-based format | Scientific Literature | |
3. | ALA1785145 | B | Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat cortical hemispheres | Rattus norvegicus | 2 | ALA1782038 | assay format | Scientific Literature | |
4. | ALA1785146 | F | Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin stimulated cAMP accumulation after 6 hrs | Homo sapiens | 19 | ALA1782038 | cell-based format | Scientific Literature | |
5. | ALA1785147 | A | Volume of distribution in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA1782038 | organism-based format | Scientific Literature | |
6. | ALA1785148 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA1782038 | organism-based format | Scientific Literature | |
7. | ALA1785149 | A | Clearance in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA1782038 | organism-based format | Scientific Literature | |
8. | ALA1785150 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA1782038 | organism-based format | Scientific Literature | |
9. | ALA1785151 | A | Half life in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA1782038 | organism-based format | Scientific Literature | |
10. | ALA1785152 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA1782038 | organism-based format | Scientific Literature | |
11. | ALA1785153 | A | Oral bioavailability Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 2 | ALA1782038 | organism-based format | Scientific Literature | |
12. | ALA1785155 | F | Ex-vivo receptor occupancy at histamine H3 receptor occupancy in po dosed Sprague-Dawley rat striatum measured 60 mins post dose by autoradiography | Rattus norvegicus | 2 | ALA1782038 | organism-based format | Scientific Literature | |
13. | ALA1785156 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA1782038 | organism-based format | Scientific Literature | |
14. | ALA3578410 | B | Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 mins | Homo sapiens | 13 | ALA3576859 | cell-based format | Scientific Literature | |
15. | ALA3578411 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as compound remaining at 1 uM after 15 mins | Rattus norvegicus | 7 | ALA3576859 | assay format | Scientific Literature | |
16. | ALA3578412 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 15 mins | Homo sapiens | 7 | ALA3576859 | assay format | Scientific Literature | |
17. | ALA3578413 | B | Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells after 60 mins by scintillation counting analysis | Homo sapiens | 7 | ALA3576859 | cell-based format | Scientific Literature | |
18. | ALA3578414 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 60 mins by LC/MS/MS analysis | Homo sapiens | 7 | ALA3576859 | cell-based format | Scientific Literature | |
19. | ALA3578415 | A | Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM after 40 mins by LC/MS/MS analysis | Homo sapiens | 7 | ALA3576859 | cell-based format | Scientific Literature | |
20. | ALA3578416 | A | Clearance in Sprague-Dawley rat | Rattus norvegicus | 7 | ALA3576859 | organism-based format | Scientific Literature |