# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1786052 | F | Antagonist activity at human TRPV1 E600V mutant expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux at 375 uM for 30 mins before capsaicin challenge measured after 48 hrs by fluorometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA1786053 | F | Antagonist activity at human TRPV1 F660A mutant expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux at 375 uM for 30 mins before capsaicin challenge measured after 48 hrs by fluorometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA1786054 | F | Antagonist activity at TRPV1 channel in C57B1 mouse dorsal root ganglion cells assessed as inhibition of capsaicin-induced calcium flux by fluorometric analysis | Mus musculus | 4 | tissue-based format | Scientific Literature | ||
4. | ALA1786675 | F | Antagonist activity at human TRPV1 expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux by fluorometric analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
5. | ALA1786677 | F | Antagonist activity at human TRPV1 expressed in human BEAS-2B cells assessed as inhibition of capsaicin-induced calcium flux at 25 to 1000 uM co-treated with 2.5 uM capsaicin measured after 30 mins by fluorometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA1786678 | F | Antagonist activity at human TRPV1 expressed in human BEAS-2B cells assessed as inhibition of capsaicin-induced calcium flux at 25 to 1000 uM preincubated for 30 mins before 2.5 uM capsaicin challenge measured after 1 min by fluorometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA1786679 | F | Antagonist activity at human TRPV1 expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux at 375 uM pretreated for 30 mins before 25 uM of capsaicin challenge measured after 1 min by fluorometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA1786680 | F | Antagonist activity at human TRPV1 expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux at 375 uM co-treated with 25 uM capsaicin after 1 min by fluorometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA1786681 | F | Antagonist activity at human TRPV1 expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux at 375 uM measured after 1 hr drug washout by fluorometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA1786686 | F | Antagonist activity at human TRPV1 C621A mutant expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux at 375 uM for 30 mins before capsaicin challenge measured after 48 hrs by fluorometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA1786687 | F | Antagonist activity at human TRPV1 C578A mutant expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux at 375 uM for 30 mins before capsaicin challenge measured after 48 hrs by fluorometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA1786688 | F | Antagonist activity at human TRPV1 N604A mutant expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux at 375 uM for 30 mins before capsaicin challenge measured after 48 hrs by fluorometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA1786689 | F | Antagonist activity at human TRPV1 E649A mutant expressed in HEK293 cell assessed as inhibition of capsaicin-induced calcium flux at 375 uM for 30 mins before capsaicin challenge measured after 48 hrs by fluorometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA4260169 | B | Antagonist activity at TRPV1 channel in mouse DRG neurons assessed as inhibition of capsaicin-induced calcium accumulation at 300 uM incubated for 6 mins by Fura-2-AM dye based fluorescence assay relative to control | Mus musculus | 7 | single protein format | Scientific Literature |