# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1806233 | Functional | Agonist activity at TrkB in E17 rat primary cortical neurons assessed as AKT phosphorylation at Ser 473 at 500 nM after 15 mins by ELISA | Rattus norvegicus | 41 | ALA1800034 | cell-based format | Scientific Literature | |
2. | ALA4431996 | Functional | Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms after 72 hrs by resazurin-based assay | Trypanosoma brucei brucei | 50 | ALA4431321 | organism-based format | Scientific Literature | |
3. | ALA4431999 | Binding | Inhibition of Trypanosoma brucei PTR1 at 50 uM using H2B as substrate incubated for 10 mins followed by addition of NADPH measured for 10 to 50 mins | Trypanosoma brucei | 10 | ALA4431321 | assay format | Scientific Literature | |
4. | ALA4432001 | Binding | Inhibition of Leishmania mexicana DHFR at 50 uM using folic aid as substrate by spectrophotometric analysis | Leishmania mexicana | 8 | ALA4431321 | assay format | Scientific Literature | |
5. | ALA4432002 | Binding | Inhibition of Trypanosoma brucei DHFR at 50 uM using folic aid as substrate by spectrophotometric analysis | Trypanosoma brucei | 8 | ALA4431321 | assay format | Scientific Literature | |
6. | ALA4432003 | Binding | Inhibition of human DHFR at 50 uM using folic aid as substrate by spectrophotometric analysis | Homo sapiens | 7 | ALA4431321 | single protein format | Scientific Literature | |
7. | ALA4432004 | Binding | Inhibition of human thymidylate synthase at 50 uM using folic aid as substrate by spectrophotometric analysis | Homo sapiens | 8 | ALA4431321 | single protein format | Scientific Literature | |
8. | ALA4432006 | Toxicity | Mitochondrial toxicity in human 786-O cells incubated for 6 hrs by mitotracker red staining based-uptake method | Homo sapiens | 16 | ALA4431321 | cell-based format | Scientific Literature | |
9. | ALA4432007 | ADME | Cytotoxicity against human A549 cells at 100 uM after 48 hrs by cell titer glo assay | Homo sapiens | 16 | ALA4431321 | cell-based format | Scientific Literature | |
10. | ALA4432008 | ADME | Cytotoxicity against human WI38 cells at 100 uM after 48 hrs by cell titer glo assay | Homo sapiens | 16 | ALA4431321 | cell-based format | Scientific Literature | |
11. | ALA4432015 | Functional | Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms at 10 uM after 72 hrs by resazurin-based assay | Trypanosoma brucei brucei | 13 | ALA4431321 | organism-based format | Scientific Literature | |
12. | ALA4432019 | ADME | Cytotoxicity against human THP1 cells after 72 hrs by MTT assay | Homo sapiens | 16 | ALA4431321 | cell-based format | Scientific Literature | |
13. | ALA4432020 | Toxicity | Selectivity index, ratio of CC50 for human THP1 cells to EC50 for Trypanosoma brucei brucei Lister 427 bloodstream forms | 16 | ALA4431321 | assay format | Scientific Literature | ||
14. | ALA4432021 | Functional | Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms assessed as synergy coefficient at 1.25 to 5 uM after 72 hrs in presence of MTX by resazurin-based assay | Trypanosoma brucei brucei | 6 | ALA4431321 | organism-based format | Scientific Literature | |
15. | ALA4432023 | ADME | Inhibition of human microsomal CYP1A2 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay | Homo sapiens | 14 | ALA4431321 | cell-based format | Scientific Literature | |
16. | ALA4629675 | Binding | Inhibition of human liver FBP1 at 200 uM incubated for 5 mins by fluorescence method relative to control | Homo sapiens | 51 | ALA4627388 | assay format | Scientific Literature |