# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1804309 | Binding | Inhibition of HDAC in human HeLa cells nuclear extract using fluor de Lys as substrate preincubated for 5 mins by fluorometric analysis | Homo sapiens | 27 | ALA1800056 | cell-based format | Scientific Literature | |
2. | ALA1804310 | Functional | Antiproliferative activity against human HCT116 cells after 72 hrs by WST-1 assay | Homo sapiens | 27 | ALA1800056 | cell-based format | Scientific Literature | |
3. | ALA1804533 | Unassigned | Ratio of GI50 for human HCT116 cells to IC50 for HDAC in human HeLa cell nuclear extracts | Homo sapiens | 25 | ALA1800056 | cell-based format | Scientific Literature | |
4. | ALA1804534 | ADME | AUC (0 to t) in plasma of CD1 mouse at 3 mg/kg, po | Mus musculus | 6 | ALA1800056 | organism-based format | Scientific Literature | |
5. | ALA1804535 | ADME | AUC (0 to t) in spleen of CD1 mouse at 3 mg/kg, po | Mus musculus | 6 | ALA1800056 | organism-based format | Scientific Literature | |
6. | ALA1804536 | ADME | Ratio of AUC (0 to t) in plasma to spleen of CD1 mouse at 3 mg/kg, po | Mus musculus | 6 | ALA1800056 | organism-based format | Scientific Literature | |
7. | ALA1804697 | ADME | Apparent permeability from apical to basolateral side of human Caco2 cells | Homo sapiens | 4 | ALA1800056 | cell-based format | Scientific Literature | |
8. | ALA1804698 | ADME | Apparent permeability from basolateral to apical side of human Caco2 cells | Homo sapiens | 4 | ALA1800056 | cell-based format | Scientific Literature | |
9. | ALA1804699 | ADME | Clearance in mouse liver microsomes assessed as compound remaining after 30 mins | Mus musculus | 4 | ALA1800056 | microsome format | Scientific Literature | |
10. | ALA1804700 | ADME | Clearance in human liver microsomes assessed as compound remaining after 30 mins | Homo sapiens | 4 | ALA1800056 | microsome format | Scientific Literature | |
11. | ALA1804701 | ADME | Inhibition of CYP2C19 | 4 | ALA1800056 | single protein format | Scientific Literature | ||
12. | ALA1804702 | ADME | Inhibition of CYP2D6 | 4 | ALA1800056 | single protein format | Scientific Literature | ||
13. | ALA1804703 | ADME | Inhibition of CYP3A4 | 4 | ALA1800056 | single protein format | Scientific Literature | ||
14. | ALA1804704 | ADME | Inhibition of CYP 2C19 at < 10 uM | 2 | ALA1800056 | single protein format | Scientific Literature | ||
15. | ALA1804705 | ADME | Inhibition of CYP2D6 at < 10 uM | 2 | ALA1800056 | single protein format | Scientific Literature | ||
16. | ALA1804706 | ADME | Inhibition of CYP3A4 at < 10 uM | 2 | ALA1800056 | single protein format | Scientific Literature | ||
17. | ALA1804707 | Physicochemical | Aqueous solubility of the compound in PBS at pH 5.5 | 4 | ALA1800056 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA1804708 | Physicochemical | Aqueous solubility of the compound in PBS at pH 7.4 | 4 | ALA1800056 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA1804709 | ADME | AUC (0 to t) in dog at 1 mg/kg, iv | Canis lupus familiaris | 2 | ALA1800056 | organism-based format | Scientific Literature | |
20. | ALA1804710 | ADME | Clearance in dog at 1 mg/kg, iv | Canis lupus familiaris | 2 | ALA1800056 | organism-based format | Scientific Literature |