# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1806337 | F | Antidiabetic activity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as normalization of fasting blood glucose level measured after 6 hrs of fasting at 2.6 mg/day administered with food for 4 weeks measured 90 mins after last dose by glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
2. | ALA1806338 | B | Selectivity ratio of IC50 for TC-PTP to IC50 for PTP1B | 1 | assay format | Scientific Literature | |||
3. | ALA1806339 | B | Selectivity ratio of IC50 for membrane proximal catalytic domain of LAR-D1 to IC50 for PTP1B | 1 | assay format | Scientific Literature | |||
4. | ALA1806340 | B | Inhibition of PTP1B expressed in Escherichia coli assessed as p-nitrophenol release from pNPP substrate preincubated for 10 mins | 21 | assay format | Scientific Literature | |||
5. | ALA1806341 | B | Inhibition of TC-PTP assessed as p-nitrophenol release from pNPP substrate preincubated for 10 mins | 1 | single protein format | Scientific Literature | |||
6. | ALA1806342 | B | Inhibition of catalytic domain of SHP-1 expressed in Escherichia coli assessed as p-nitrophenol release from pNPP substrate preincubated for 10 mins | 1 | assay format | Scientific Literature | |||
7. | ALA1806343 | B | Inhibition of membrane proximal catalytic domain of LAR-D1 assessed as p-nitrophenol release from pNPP substrate preincubated for 10 mins | 1 | assay format | Scientific Literature | |||
8. | ALA1806344 | B | Inhibition of YOP assessed as p-nitrophenol release from pNPP substrate preincubated for 10 mins | 1 | assay format | Scientific Literature | |||
9. | ALA1805524 | B | Inhibition of yeast PTP1 expressed in Escherichia coli assessed as p-nitrophenol release from pNPP substrate preincubated for 10 mins | Saccharomyces cerevisiae | 1 | assay format | Scientific Literature | ||
10. | ALA1805525 | F | Agonist activity at PPARgamma expressed in HepG2 cells co-expressing PPRE assessed as concentration required for maximal activation after 24 hrs by luciferase reporter gene assay | 2 | cell-based format | Scientific Literature | |||
11. | ALA1805526 | F | Agonist activity at PPARgamma expressed in HepG2 cells co-expressing PPRE assessed as transcriptional activation after 24 hrs by luciferase reporter gene assay | 2 | cell-based format | Scientific Literature | |||
12. | ALA1805527 | F | Antiobesity activity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as reduction in body weight at 2.6 mg/day administered with food for 4 weeks | Mus musculus | 2 | organism-based format | Scientific Literature | ||
13. | ALA1805528 | F | Antiobesity activity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as weight gain/kcal at 2.6 mg/day administered with food for 4 weeks | Mus musculus | 2 | organism-based format | Scientific Literature | ||
14. | ALA1805529 | F | Antiobesity activity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as decrease in epididymal fat at 2.6 mg/day administered with food for 4 weeks | Mus musculus | 2 | organism-based format | Scientific Literature | ||
15. | ALA1805530 | F | Antiobesity activity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as decrease in retroperitoneal fat at 2.6 mg/day administered with food for 4 weeks | Mus musculus | 2 | organism-based format | Scientific Literature | ||
16. | ALA1805531 | T | Toxicity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as change in weight of liver at 2.6 mg/day administered with food for 4 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA1805532 | T | Toxicity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as change in weight of kidney at 2.6 mg/day administered with food for 4 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA1805533 | T | Toxicity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as change in weight of lung at 2.6 mg/day administered with food for 4 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
19. | ALA1805535 | F | Antiobesity activity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as decrease in total cholesterol level in serum at 2.6 mg/day administered with food for 4 weeks | Mus musculus | 2 | organism-based format | Scientific Literature | ||
20. | ALA1805536 | F | Antiobesity activity in high fat diet-fed diabetic C57BL/6J Jms Slc mouse model assessed as decrease in serum triglyceride level at 2.6 mg/day administered with food for 4 weeks | Mus musculus | 2 | organism-based format | Scientific Literature |