# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1811529 | A | Intrinsic clearance in rat liver microsomes assessed per gram of liver | Rattus norvegicus | 11 | ALA1806396 | microsome format | Scientific Literature | |
2. | ALA1811531 | F | Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant after 3 days by CellTiter-Glo assay | Homo sapiens | 20 | ALA1806396 | cell-based format | Scientific Literature | |
3. | ALA1811532 | B | Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr | Homo sapiens | 19 | ALA1806396 | cell-based format | Scientific Literature | |
4. | ALA1811533 | B | Inhibition of B-Raf V600E mutant | Homo sapiens | 19 | ALA1806396 | assay format | Scientific Literature | |
5. | ALA2340071 | A | Oral bioavailability in monkey | Macaca mulatta | 1 | ALA2331286 | organism-based format | Scientific Literature | |
6. | ALA2340073 | A | Oral bioavailability in dog | Canis lupus familiaris | 1 | ALA2331286 | organism-based format | Scientific Literature | |
7. | ALA2345966 | A | Dose-normalized AUC in po dosed monkey | Macaca mulatta | 1 | ALA2331286 | organism-based format | Scientific Literature | |
8. | ALA2345967 | A | Oral bioavailability in rat | Rattus norvegicus | 1 | ALA2331286 | organism-based format | Scientific Literature | |
9. | ALA2345968 | A | Dose-normalized AUC in po dosed dog | Canis lupus familiaris | 12 | ALA2331286 | organism-based format | Scientific Literature | |
10. | ALA2345969 | A | Blood clearance in iv dosed monkey | Macaca mulatta | 1 | ALA2331286 | organism-based format | Scientific Literature | |
11. | ALA2345970 | A | Dose-normalized AUC in po dosed rat | Rattus norvegicus | 12 | ALA2331286 | organism-based format | Scientific Literature | |
12. | ALA2345971 | A | Blood clearance in iv dosed dog | Canis lupus familiaris | 12 | ALA2331286 | organism-based format | Scientific Literature | |
13. | ALA2345972 | A | Blood clearance in iv dosed rat | Rattus norvegicus | 12 | ALA2331286 | organism-based format | Scientific Literature | |
14. | ALA2345973 | A | Intrinsic clearance in dog liver microsome at 10 uM after 30 mins by LC/MS analysis | Canis lupus familiaris | 1 | ALA2331286 | microsome format | Scientific Literature | |
15. | ALA2345974 | A | Intrinsic clearance in monkey liver microsome | Macaca mulatta | 1 | ALA2331286 | assay format | Scientific Literature | |
16. | ALA2345975 | A | Intrinsic clearance in rat liver microsome | Rattus norvegicus | 1 | ALA2331286 | microsome format | Scientific Literature | |
17. | ALA2345976 | F | Inhibition of B-Raf V600E mutant-driven SK-MEL-28 cell proliferation after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 12 | ALA2331286 | cell-based format | Scientific Literature | |
18. | ALA2345977 | B | Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as decrease in ERK phosphorylation incubated for 1 hr by immunoassay | Homo sapiens | 12 | ALA2331286 | cell-based format | Scientific Literature | |
19. | ALA2345978 | B | Inhibition of N-terminal His tagged B-Raf V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 assessed as decrease in biotinylated-MEK protein phosphorylation by AlphaScreen assay | Homo sapiens | 12 | ALA2331286 | cell-based format | Scientific Literature | |
20. | ALA3988182 | F | GSK PKIS2: Screen against O. lienalis microfilariae, single point, at 3.1uM to assess reduction in motility. Compounds were also tested for cytotoxicity against Rhesus Monkey LLCMK2 cells. A score was assigned as follows: Score 3 = Good activity, 100 % motility reduction; Score 2 = Marginal/moderate activity, 50-99% motility reduction; Score 1 = Inactive, <50% motility reduction; Score 0 = Cytotoxic. | Onchocerca lienalis | 486 | ALA3988181 | cell-based format | Published Kinase Inhibitor Set 2 |