# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3630807 | Binding | Inhibition of human TDO | Homo sapiens | 2 | ALA3627665 | single protein format | Scientific Literature | |
2. | ALA3630808 | Binding | Inhibition of mouse TDO | Mus musculus | 2 | ALA3627665 | single protein format | Scientific Literature | |
3. | ALA3630809 | Binding | Inhibition of mouse IDO1 | Mus musculus | 2 | ALA3627665 | single protein format | Scientific Literature | |
4. | ALA1817445 | ADME | Plasma concentration in DBA/2 mouse at 160 mg/kg/day, po administered for 7 days with water | Mus musculus | 3 | ALA1811872 | organism-based format | Scientific Literature | |
5. | ALA1817446 | Binding | Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs by HPLC analysis | Mus musculus | 76 | ALA1811872 | cell-based format | Scientific Literature | |
6. | ALA1817447 | Functional | Cytotoxicity against mouse P815B cells after 8 hrs by MTT assay | Mus musculus | 76 | ALA1811872 | cell-based format | Scientific Literature | |
7. | ALA1817448 | Physicochemical | Chemical stability of the compound in phosphate buffered saline assessed as compound remaining at pH 7.4 after 1.5 hrs | 3 | ALA1811872 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA1817449 | Binding | Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formylkynurenine into kynurenine after 30 mins by Michaelis-Menten steady state analysis | Homo sapiens | 4 | ALA1811872 | assay format | Scientific Literature | |
9. | ALA1817450 | Physicochemical | Solubility of the compound in phosphate buffered saline at pH 7.4 | 3 | ALA1811872 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA1817452 | Binding | Inhibition of IDO at 10 uM | 1 | ALA1811872 | single protein format | Scientific Literature | ||
11. | ALA1816020 | Binding | Inhibition of MAO-A at 10 uM relative to control | 1 | ALA1811872 | single protein format | Scientific Literature | ||
12. | ALA1816021 | Binding | Inhibition of MAO-B at 10 uM relative to control | 1 | ALA1811872 | single protein format | Scientific Literature | ||
13. | ALA1816022 | Binding | Displacement of [3H]prazosin from adrenergic alpha1 receptor at 10 uM relative to control | 1 | ALA1811872 | assay format | Scientific Literature | ||
14. | ALA1816023 | Binding | Displacement of [3H]RX821002 from adrenergic alpha2 receptor at 10 uM relative to control | 1 | ALA1811872 | assay format | Scientific Literature | ||
15. | ALA1816024 | Binding | Displacement of [3H](-)-CGP12177 from human adrenergic beta1 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA1811872 | single protein format | Scientific Literature | |
16. | ALA1816025 | Binding | Displacement of [3H](-)-CGP12177 from human adrenergic beta2 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA1811872 | single protein format | Scientific Literature | |
17. | ALA1816026 | Binding | Displacement of [3H]SCH23390 from human dopamine D1 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA1811872 | single protein format | Scientific Literature | |
18. | ALA1816027 | Binding | Displacement of [3H]methyl-spiperone from human dopamine D2s receptor at 10 uM relative to control | Homo sapiens | 1 | ALA1811872 | single protein format | Scientific Literature | |
19. | ALA1816028 | Binding | Displacement of [125I]2-iodomelatonin from human MT1 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA1811872 | single protein format | Scientific Literature | |
20. | ALA1816029 | Binding | Displacement of [3H]8-OH-DPAT from human 5HT1A receptor at 10 uM relative to control | Homo sapiens | 1 | ALA1811872 | single protein format | Scientific Literature |